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NCT05677594 · ClinicalTrials.gov registry record
Multi-parametric Biomarker Development to Predict Malignant Conversion in Patients With Neurofibromatosis Type 1
A clinical trial of Neurofibromatosis 1 and Atypical Neurofibroma, sponsored by Johns Hopkins University.
- Active
- Registry status
- 80
- Enrollment target
- 1
- Study location
NCT05677594 is a study of Neurofibromatosis 1 and Atypical Neurofibroma that is active but no longer recruiting, run by Johns Hopkins University. The registered enrollment target is 80 participants, below the 1,032-participant average among 24 other Neurofibromatosis 1 trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05677594, a study of Neurofibromatosis 1 and Atypical Neurofibroma, is active but no longer recruiting, sponsored by Johns Hopkins University.
- ACTIVE NOT RECRUITING
- Registry status
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this prospective observational study is to learn about the utility of imaging and clinical features in patients with Neurofibromatosis type 1 categorized as high risk for the development of malignant peripheral nerve sheath tumors. The main objectives are: * To evaluate the prevalence, multi-parametric imaging features of distinct nodular lesions ("DNLs") and natural history in people with NF1 with clinical and genetic features deemed "high-risk" for malignancy. * To assess the relationship between individual clinical, genetic and imaging factors that have been suggested to be risk factors for malignant peripheral nerve sheath tumors (MPNST) and the confirmation of atypical neurofibromas (aNF)/ atypical neurofibromatous neoplasm of unknown biologic potential (ANNUBP) or MPNST on pathology. In this research study, the participants will be asked to undergo whole body MRI, provide blood sample and clinical evaluation annually.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Whole Body Magnetic Resonance Imaging
Study Locations (1)
Maryland
- Johns Hopkins University - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2021-07-01 |
| Est. Completion | 2028-06-30 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05677594
The ClinicalTrials.gov registry entry for NCT05677594 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,032-participant average among 24 other Neurofibromatosis 1 trials with a reported enrollment target (92% lower). The listed sponsor is Johns Hopkins University, which has 1,448 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Neurofibromatosis 1 appearing as the primary indexed condition, and to 1 intervention - of which Whole Body Magnetic Resonance Imaging is the first listed.
NCT05677594 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.
Frequently Asked Questions
What is clinical trial NCT05677594 about?
NCT05677594 is a clinical study titled "Multi-parametric Biomarker Development to Predict Malignant Conversion in Patients With Neurofibromatosis Type 1". The goal of this prospective observational study is to learn about the utility of imaging and clinical features in patients with Neurofibromatosis type 1 categorized as high risk for the development of malignant peripheral nerve sheath tumors. The main objectives are: * To evaluate the prevalence,...
What is the current status of trial NCT05677594?
This trial is currently active not recruiting. The enrollment target is 80 participants. The study started on 2021-07-01. Estimated completion is 2028-06-30.
What conditions does trial NCT05677594 study?
This clinical trial studies the following conditions: Neurofibromatosis 1, Atypical Neurofibroma, Malignant Peripheral Nerve Sheath Tumor (MPNST) of Soft Tissue (Diagnosis).
What interventions are being tested in trial NCT05677594?
The interventions under investigation include: Whole Body Magnetic Resonance Imaging (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT05677594?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05677594 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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