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NCT05656027 · ClinicalTrials.gov registry record · Phase 3
Phase 3 Evaluation of the Safety and Efficacy of LNZ100 & LNZ101 for the Treatment of Presbyopia
A Phase 3 study, sponsored by LENZ Therapeutics.
- Completed
- Registry status
- Phase 3
- Development phase
- 469
- Enrollment target
NCT05656027: Completed Phase 3 study, sponsored by LENZ Therapeutics.
NCT05656027 is a Phase 3 study that has completed, run by LENZ Therapeutics. The registered enrollment target is 469 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (39% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05656027, a Phase 3 study, has completed, sponsored by LENZ Therapeutics.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 469 participants
- Enrollment target
Study Summary
Phase 3 study to evaluate the safety and effectiveness of LNZ100 \& LNZ101 for the treatment of Presbyopia.
Primary Outcome
Percentage of participants with at least a 3-line improvement in near vision and no loss ≥ 5 letters distance vision on Day 1
Interventions
- DRUG Aceclidine+Brimonidine combination ophthalmic solution
- DRUG Aceclidine ophthalmic solution
- DRUG Brimonidine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 469 participants |
| Start Date | 2022-12-19 |
| Est. Completion | 2024-01-25 |
| Phase | Phase 3 |
What the finished NCT05656027 record still lists
NCT05656027 is an interventional study that assigns participants to a tested intervention. The registered 469 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (39% lower).
The record links to 0 conditions, and to 3 interventions - of which Aceclidine+Brimonidine combination ophthalmic solution is the first listed.
NCT05656027 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05656027 about?
NCT05656027 is a clinical study titled "Phase 3 Evaluation of the Safety and Efficacy of LNZ100 & LNZ101 for the Treatment of Presbyopia". Phase 3 study to evaluate the safety and effectiveness of LNZ100 \& LNZ101 for the treatment of Presbyopia.
What is the current status of trial NCT05656027?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 469 participants. The study started on 2022-12-19. Estimated completion is 2024-01-25.
What interventions are being tested in trial NCT05656027?
The interventions under investigation include: Aceclidine+Brimonidine combination ophthalmic solution (DRUG), Aceclidine ophthalmic solution (DRUG), Brimonidine (DRUG).
Who is sponsoring clinical trial NCT05656027?
This trial is sponsored by LENZ Therapeutics, which has 8 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05656027's enrollment target sits among peer trials
469 815th of 2000 higher than 1,185 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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