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NCT05655143 · ClinicalTrials.gov registry record · NA
Effects of Balance Training on Corticospinal Excitability in People With Chronic Ankle Instability
A NA study, sponsored by Old Dominion University.
- Completed
- Registry status
- NA
- Development phase
- 30
- Enrollment target
NCT05655143 is a NA study that has completed, run by Old Dominion University. The registered enrollment target is 30 participants.
The verdict
NCT05655143, a NA study, has completed, sponsored by Old Dominion University.
- COMPLETED
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
Study Summary
Ankle sprains are prevalent and debilitating injuries in daily living and sports activities. The emergency room annually cares for over 206,000 patients with lateral ankle sprain in the United States, resulting in over $12,000 of health care cost per injury. Although many rehabilitation techniques for ankle sprains have been implemented, up to 40% of individuals with ankle sprains experience residual symptoms including recurrent sprain, episodes of ankle joint "giving way," and feelings of instability, which collectively define chronic ankle instability (CAI). Individuals with CAI commonly exhibit neuromuscular dysfunction with reduced motor control due to decreased sensory input to the central nervous system (CNS) after the initial injury. As a result, the CNS sends altered motor signals to lower extremity muscles. These CNS changes contribute to various neuromuscular impairments in CAI patients, the most common of which is reduced balance performance. Neural stimulation techniques, such as the Hoffman reflex (H-reflex) and transcranial magnetic stimulation (TMS) have been used to directly assess changes in the CNS. One of the most consistently identified CNS changes in individuals with CAI is reduced ability to modulate spinal reflex excitability and corticospinal excitability of the calf muscle when transitioning from simpler to more complex balance conditions. Neural excitability refers to the ability of the central nervous system to elicit skeletal muscle contractions. That is, the spinal reflex excitability and corticospinal excitability can be described as the ability to contract muscle conducted by the spine and brain, respectively. Typically, healthy individuals modulate or quiet down their spinal reflexes and rely more on the corticospinal excitability during more demanding balance tasks. However, evidence indicates that the individuals with CAI are unable to modulate spinal reflexes and shift control to brain, leading to reduced balance performance. Give
Interventions
- BEHAVIORAL Balance training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2022-12-06 |
| Est. Completion | 2024-03-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05655143
The ClinicalTrials.gov registry entry for NCT05655143 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Old Dominion University, which has 23 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Balance training is the first listed.
NCT05655143 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT05655143 about?
NCT05655143 is a clinical study titled "Effects of Balance Training on Corticospinal Excitability in People With Chronic Ankle Instability". Ankle sprains are prevalent and debilitating injuries in daily living and sports activities. The emergency room annually cares for over 206,000 patients with lateral ankle sprain in the United States, resulting in over $12,000 of health care cost per injury. Although many rehabilitation techniques f...
What is the current status of trial NCT05655143?
This trial is currently completed. It is a NA study. The enrollment target is 30 participants. The study started on 2022-12-06. Estimated completion is 2024-03-31.
What interventions are being tested in trial NCT05655143?
The interventions under investigation include: Balance training (BEHAVIORAL).
Who is sponsoring clinical trial NCT05655143?
This trial is sponsored by Old Dominion University, which has 23 total clinical trials registered on ClinicalTrials.gov.
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