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NCT05651334 · ClinicalTrials.gov registry record · Phase 2
Transcranial Magnetic Stimulation in Smokers: an Examination of Mediating Neural Pathways.
A Phase 2 study, sponsored by Kent State University.
- Completed
- Registry status
- Phase 2
- Development phase
- 6
- Enrollment target
NCT05651334: Completed Phase 2 study, sponsored by Kent State University.
NCT05651334 is a Phase 2 study that has completed, run by Kent State University. The registered enrollment target is 6 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05651334, a Phase 2 study, has completed, sponsored by Kent State University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 6 participants
- Enrollment target
Study Summary
The primary objective of this study is to examine the effects of repetitive transcranial magnetic stimulation (rTMS) on a regulation of craving task (ROC task) and evaluate the feasibility of targeting rTMS via fMRI based neuronavigation. Specifically, we will examine BOLD activation within the DLPFC when control over craving is exerted in order to identify if 1) the task produces reliable activations in an area capable of being targeted by a standard figure-8 coil and 2) examine if the coordinates of the area are distinct from the area targeted via anatomical neuronavigation alone. Last, we will examine if rTMS, compared to sham, is capable of improving cognitive control over craving measured at outcome. The current pilot study will examine these aims in a sample of tobacco dependent adults (N=16) (with final sample size dependent on availability of funds).
Primary Outcome
Self report ratings of cue induced craving for smoking after instruction. Specifically, differences in craving following positive vs. negative instructions will be compared between active stimulation and sham stimulation groups at the final outcome session, accounting for baseline values (similar to methods detailed in (Kober, Kross, Mischel, Hart, \& Ochsner, 2010). Kober, H., Kross, E. F., Mischel, W., Hart, C. L., \& Ochsner, K. N. (2010). Regulation of craving by cognitive strategies in cig
Interventions
- DEVICE Sham repetitive Transcranial Magnetic Stimulation
- DEVICE Active repetitive Transcranial Magnetic Stimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6 participants |
| Start Date | 2022-11-08 |
| Est. Completion | 2023-07-13 |
| Phase | Phase 2 |
What the finished NCT05651334 record still lists
NCT05651334 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 6 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 2 interventions - of which Sham repetitive Transcranial Magnetic Stimulation is the first listed.
NCT05651334 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05651334 about?
NCT05651334 is a clinical study titled "Transcranial Magnetic Stimulation in Smokers: an Examination of Mediating Neural Pathways.". The primary objective of this study is to examine the effects of repetitive transcranial magnetic stimulation (rTMS) on a regulation of craving task (ROC task) and evaluate the feasibility of targeting rTMS via fMRI based neuronavigation. Specifically, we will examine BOLD activation within the DLPF...
What is the current status of trial NCT05651334?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 6 participants. The study started on 2022-11-08. Estimated completion is 2023-07-13.
What interventions are being tested in trial NCT05651334?
The interventions under investigation include: Sham repetitive Transcranial Magnetic Stimulation (DEVICE), Active repetitive Transcranial Magnetic Stimulation (DEVICE).
Who is sponsoring clinical trial NCT05651334?
This trial is sponsored by Kent State University, which has 19 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05651334's enrollment target sits among peer trials
6 1996th of 2000 higher than 1 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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