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NCT05636540 · ClinicalTrials.gov registry record · Early Phase 1
In Vivo PARP-1 Expression With 18F-FluorThanatrace PET/CT in Patients With Pheochromocytoma and Paraganglioma
A Early Phase 1 study of Pheochromocytoma and Paraganglioma, sponsored by Heather Wachtel.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT05636540: Recruiting Early Phase 1 study of Pheochromocytoma and Paraganglioma, sponsored by Heather Wachtel.
NCT05636540 is a Early Phase 1 study of Pheochromocytoma and Paraganglioma that is actively recruiting participants, run by Heather Wachtel. The registered enrollment target is 30 participants, below the 518-participant average among 14 other Pheochromocytoma trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05636540, a Early Phase 1 study of Pheochromocytoma and Paraganglioma, is actively recruiting participants, sponsored by Heather Wachtel.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will enroll up to 30 evaluable patients with pheochromocytoma or paraganglioma who are undergoing surgical or systemic treatment. A pre-treatment 18F-FluorThanatrace (\[18F\]FTT) positron emission tomography/computed tomography (PET/CT) scan will be done prior to surgery or systemic therapy. PET/CT imaging will be used to evaluate PARP-1 expression in sites of pheochromocytoma or paraganglioma using the investigational radiotracer \[18F\]FTT. This is an observational study in that \[18F\]FTT PET/CT will not be used to direct treatment decisions. While patients and referring physicians will not be blinded to the \[18F\]FTT PET/CT results, treatment decisions will be made by the treating physicians based upon clinical criteria.
Primary Outcome
Qualitative measure SUV of \[18F\]FTT in phenochromocytoma/paraganlioma region (categories: positive, negative or mixed)
Conditions Studied
Interventions
- DRUG [18F]FluorThanatrace ([18F]FTT)
Study Locations (1)
Pennsylvania
- Abramson Cancer Center of the University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2023-07-01 |
| Est. Completion | 2026-12-31 |
| Phase | Early Phase 1 |
What NCT05636540 shows while recruiting
NCT05636540 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 518-participant average among 14 other Pheochromocytoma trials with a reported enrollment target (94% lower).
The record links to 2 conditions, with Pheochromocytoma appearing as the primary indexed condition, and to 1 intervention - of which [18F]FluorThanatrace ([18F]FTT) is the first listed.
NCT05636540 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05636540 about?
NCT05636540 is a clinical study titled "In Vivo PARP-1 Expression With 18F-FluorThanatrace PET/CT in Patients With Pheochromocytoma and Paraganglioma". This study will enroll up to 30 evaluable patients with pheochromocytoma or paraganglioma who are undergoing surgical or systemic treatment. A pre-treatment 18F-FluorThanatrace (\[18F\]FTT) positron emission tomography/computed tomography (PET/CT) scan will be done prior to surgery or systemic ther...
What is the current status of trial NCT05636540?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 30 participants. The study started on 2023-07-01. Estimated completion is 2026-12-31.
What conditions does trial NCT05636540 study?
This clinical trial studies the following conditions: Pheochromocytoma, Paraganglioma.
What interventions are being tested in trial NCT05636540?
The interventions under investigation include: [18F]FluorThanatrace ([18F]FTT) (DRUG).
Who is sponsoring clinical trial NCT05636540?
This trial is sponsored by Heather Wachtel, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05636540 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05636540's enrollment target sits among peer trials
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participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pheochromocytoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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