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NCT05634577 · ClinicalTrials.gov registry record · Phase 2
A Phase II Study to Evaluate the Efficacy and Safety of Pembrolizumab in Combination With Mitotane in Patients With Advanced Adrenocortical Carcinoma
A Phase 2 study, sponsored by M.D. Anderson Cancer Center.
- Terminated
- Registry status
- Phase 2
- Development phase
- 3
- Enrollment target
NCT05634577: Clinical Trial Phase 2 study, sponsored by M.D. Anderson Cancer Center.
NCT05634577 is a Phase 2 study that was terminated before completion, run by M.D. Anderson Cancer Center. The registered enrollment target is 3 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05634577, a Phase 2 study, was terminated before completion, sponsored by M.D. Anderson Cancer Center.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 3 participants
- Enrollment target
Study Summary
To learn if adding pembrolizumab to mitotane can help to control ACC. The safety of this drug combination will also be studied.
Primary Outcome
Assessment of tumor reduction by RECIST1.1 criteria
Interventions
- DRUG Pembrolizumab
- DRUG Mitotane
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2023-03-23 |
| Est. Completion | 2024-07-10 |
| Phase | Phase 2 |
Why NCT05634577 stopped before completion
NCT05634577 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 3 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Pembrolizumab is the first listed.
NCT05634577 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05634577 about?
NCT05634577 is a clinical study titled "A Phase II Study to Evaluate the Efficacy and Safety of Pembrolizumab in Combination With Mitotane in Patients With Advanced Adrenocortical Carcinoma". To learn if adding pembrolizumab to mitotane can help to control ACC. The safety of this drug combination will also be studied.
What is the current status of trial NCT05634577?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 3 participants. The study started on 2023-03-23. Estimated completion is 2024-07-10.
What interventions are being tested in trial NCT05634577?
The interventions under investigation include: Pembrolizumab (DRUG), Mitotane (DRUG).
Who is sponsoring clinical trial NCT05634577?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05634577's enrollment target sits among peer trials
3 2001st of 2000 the lowest of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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