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A Study to Evaluate MORF-057 in Adults With Moderately to Severely Active UC
NCT05611671 · View on ClinicalTrials.gov ↗
Study Summary
This is a Phase 2b randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of three active dose regimens of MORF-057 in adult patients with moderately to severely active Ulcerative Colitis (UC).
Conditions Studied
Interventions
- DRUG Placebo
- DRUG MORF-057
Study Locations (20)
Other
- Blacktown Hospital — Blacktown
- Concord Repatriation General Hospital — Concord
- Royal Brisbane and Women's Hospital — Herston
- Fiona Stanley Hospital — Murdoch
- Mater Adult Hospital Brisbane — South Brisbane
- Order Hospital Linz Ltd. - Hospital of Sisters of Mercy — Linz
- Salzburg Regional Hospital — Salzburg
- Medical University of Vienna — Vienna
- Medical Center "Rusemed" EOOD — Rousse
- University Multiprofile Hospital for Active Treatment "ACIBADEM City Clinic" — Sofia
- Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda — Sofia
- Second Multiprofile Hospital for Active Treatment - Sofia — Sofia
California
- Gastro Care Institute — Lancaster
- TLC Clinical Research Inc. — Los Angeles
Florida
- Innova Clinical Trials — Coral Gables
- Eminat, LLC - Miramar — Miramar
Arizona
- Arizona Digestive Health - Sun City — Sun City
New Jersey
- Robert Wood Johnson University Medical School — New Brunswick
Ohio
- Great Lakes Gastroenterology — Mentor
Texas
- The University of Texas Health Science Center at Houston — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 280 participants |
| Start Date | 2022-11-21 |
| Est. Completion | 2026-08 |
| Phase | Phase 2 |
Sponsor
Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)3 total trials
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05611671
The ClinicalTrials.gov registry entry for NCT05611671 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 280 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company), which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Inflammatory Bowel Diseases appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05611671 reports 20 study locations spanning 7 distinct geographic areas — top geographies include Other, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05611671 about?
NCT05611671 is a clinical study titled "A Study to Evaluate MORF-057 in Adults With Moderately to Severely Active UC". This is a Phase 2b randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of three active dose regimens of MORF-057 in adult patients with moderately to severely active Ulcerative Colitis (UC).
What is the current status of trial NCT05611671?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 280 participants. The study started on 2022-11-21. Estimated completion is 2026-08.
What conditions does trial NCT05611671 study?
This clinical trial studies the following conditions: Inflammatory Bowel Diseases, Colitis, Ulcerative. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05611671?
The interventions under investigation include: Placebo (DRUG), MORF-057 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05611671?
This trial is sponsored by Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company), which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05611671 being conducted?
This trial has 20 study locations across Arizona, California, Florida, New Jersey, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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