Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05607017 · ClinicalTrials.gov registry record · Early Phase 1
Losartan in Prevention of Radiation-Induced Heart Failure
A Early Phase 1 study, sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 5
- Enrollment target
NCT05607017: Completed Early Phase 1 study, sponsored by Massachusetts General Hospital.
NCT05607017 is a Early Phase 1 study that has completed, run by Massachusetts General Hospital. The registered enrollment target is 5 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (91% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05607017, a Early Phase 1 study, has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 5 participants
- Enrollment target
Study Summary
This study is being done to see if losartan affects the chances of developing radiation-induced heart failure in patients who are receiving radiation therapy as part of standard of care treatment for breast cancer. The interventions involved in this study are: * Losartan * Radiation Therapy (standard of care)
Primary Outcome
The primary endpoint is detectable decrease in extracellular volume as measured by cardiac MRI
Interventions
- RADIATION Radiation Therapy
- DRUG Losartan
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2023-09-13 |
| Est. Completion | 2025-10-07 |
| Phase | Early Phase 1 |
What the finished NCT05607017 record still lists
NCT05607017 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (91% lower).
The record links to 0 conditions, and to 2 interventions - of which Radiation Therapy is the first listed.
NCT05607017 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05607017 about?
NCT05607017 is a clinical study titled "Losartan in Prevention of Radiation-Induced Heart Failure". This study is being done to see if losartan affects the chances of developing radiation-induced heart failure in patients who are receiving radiation therapy as part of standard of care treatment for breast cancer. The interventions involved in this study are: * Losartan * Radiation Therapy (stand...
What is the current status of trial NCT05607017?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 5 participants. The study started on 2023-09-13. Estimated completion is 2025-10-07.
What interventions are being tested in trial NCT05607017?
The interventions under investigation include: Radiation Therapy (RADIATION), Losartan (DRUG).
Who is sponsoring clinical trial NCT05607017?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05607017's enrollment target sits among peer trials
5 1888th of 2000 higher than 80 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI