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NCT05602220 · ClinicalTrials.gov registry record · NA
Heart Rate and Breathing Effects on Attention and Memory
A NA study, sponsored by University of Southern California.
- Completed
- Registry status
- NA
- Development phase
- 91
- Enrollment target
NCT05602220: Completed NA study, sponsored by University of Southern California.
NCT05602220 is a NA study that has completed, run by University of Southern California. The registered enrollment target is 91 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05602220, a NA study, has completed, sponsored by University of Southern California.
- COMPLETED
- Registry status
- NA
- Development phase
- 91 participants
- Enrollment target
Study Summary
In the current study, we will examine how daily paced breathing affects plasma amyloid beta levels and the rate of learning in older adults. Healthy adults aged 50-70 who meet all eligibility criteria will be invited to this study. Participants will be randomly assigned to one of the two conditions: 1) Daily memory and attention training followed by a paced breathing protocol designed to increase relaxation or 2) Daily memory and attention training followed by a paced breathing protocol to increase alertness. Participants will be asked to complete pre and post intervention cognitive testing online, engage in 10 weeks of daily brain training (starting Week 2) and 9 weeks of paced breathing (starting Week 3) at home. They will also be asked to come in for lab visits on Weeks 2, 7 and 12 to provide blood and urine samples to assess amyloid beta levels and to complete magnetic resonance imaging scans to assess perivascular space volume.
Primary Outcome
We computed an aggregate Z-score based on plasma Aβ40 and Aβ42 levels (pg/mL). A Z-score of 0 represents the sample mean. Higher values indicate a greater level of plasma Aβ, which in cognitively normal individuals has been found to be associated with a higher risk of converting to Alzheimer's disease (Song et al., 2011). This score was compared across three time points: Week 2 (pre-intervention), Week 7 (mid-intervention), and Week 12 (post-intervention). We conducted a time (Week 2, 7, 12) × c
Interventions
- BEHAVIORAL Paced breathing
- BEHAVIORAL Brain training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 91 participants |
| Start Date | 2023-01-11 |
| Est. Completion | 2023-11-13 |
| Phase | NA |
What the finished NCT05602220 record still lists
NCT05602220 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 91 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 2 interventions - of which Paced breathing is the first listed.
NCT05602220 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05602220 about?
NCT05602220 is a clinical study titled "Heart Rate and Breathing Effects on Attention and Memory". In the current study, we will examine how daily paced breathing affects plasma amyloid beta levels and the rate of learning in older adults. Healthy adults aged 50-70 who meet all eligibility criteria will be invited to this study. Participants will be randomly assigned to one of the two conditions:...
What is the current status of trial NCT05602220?
This trial is currently completed. It is a NA study. The enrollment target is 91 participants. The study started on 2023-01-11. Estimated completion is 2023-11-13.
What interventions are being tested in trial NCT05602220?
The interventions under investigation include: Paced breathing (BEHAVIORAL), Brain training (BEHAVIORAL).
Who is sponsoring clinical trial NCT05602220?
This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05602220's enrollment target sits among peer trials
91 939th of 2000 higher than 1,060 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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