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NCT05598034 · ClinicalTrials.gov registry record · NA
Evaluating tDCS Brain-stimulation in Depression Using MRI
A NA study of Major Depressive Disorder, sponsored by University of California, Los Angeles.
- Recruiting
- Registry status
- NA
- Development phase
- 144
- Enrollment target
- 1
- Study location
NCT05598034: Recruiting NA study of Major Depressive Disorder, sponsored by University of California, Los Angeles.
NCT05598034 is a NA study of Major Depressive Disorder that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 144 participants, below the 376-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (62% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05598034, a NA study of Major Depressive Disorder, is actively recruiting participants, sponsored by University of California, Los Angeles.
- RECRUITING
- Registry status
- NA
- Development phase
- 144 participants
- Enrollment target
- 1
- Study location
Study Summary
Patients, physicians, and those who fund depression research are keenly interested in depression treatments that do not involve taking medications. One promising candidate treatment is transcranial direct current stimulation (tDCS), a low-cost technique that involves placing electrodes on specific scalp locations and using a 9-volt battery to cause a small amount of electricity to pass through parts of the brain. Depending on the direction of electrical flow, tDCS can make brain cells (neurons) more likely or less likely to generate their own electrical signals. When evaluated as a treatment, tDCS is typically done in daily sessions over a period of two weeks. One of the challenges of tDCS is to work out the best possible positioning of electrodes and direction of electricity flow to gradually cause lasting changes in brain activity in ways that might be expected to improve depression. To address this challenge, the investigators are using MRI to take pictures of the brain during tDCS. This data will help us better understand the short-term effects of tDCS in depression and help us learn how to customize future treatments to cause a lasting beneficial response. Patients with depression between the ages of 20-55 years are eligible to take part in this research. Potential participants will undergo: 1. An assessment to confirm eligibility. This will take place over a secure videoconference call lasting no more than 3 hours. 2. Two in-person study visits lasting 30 min and 2-1/2 hours respectively. In the first visit, the investigators will use the MRI to take a picture of the brain and head structure to determine appropriate locations for placing the tDCS electrodes at the start of the second visit. Following electrode placement, an MRI scan will be performed to take pictures of the brain during tDCS. Depending on the study arm, 1. Participants may receive 'active' or 'sham' tDCS. The 'sham' condition is identical to the 'active' tDCS in every way except that it
Primary Outcome
fMRI-BOLD signal within nodes of the dorso-fronto-limbic brain network will be analyzed for activity changes concurrent with tDCS
Conditions Studied
Interventions
- DEVICE Left DLPFC tDCS
- DEVICE Right DLPFC tDCS
- BEHAVIORAL Cognitive task
Study Locations (1)
California
- University of California Los Angeles (UCLA) - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 144 participants |
| Start Date | 2022-10-20 |
| Est. Completion | 2027-05-01 |
| Phase | NA |
What NCT05598034 shows while recruiting
NCT05598034 is an interventional study that assigns participants to a tested intervention. The registered 144 participants enrollment target is mid-sized for trials with a published cap, below the 376-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (62% lower).
The record links to 1 condition, with Major Depressive Disorder appearing as the primary indexed condition, and to 3 interventions - of which Left DLPFC tDCS is the first listed.
NCT05598034 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05598034 about?
NCT05598034 is a clinical study titled "Evaluating tDCS Brain-stimulation in Depression Using MRI". Patients, physicians, and those who fund depression research are keenly interested in depression treatments that do not involve taking medications. One promising candidate treatment is transcranial direct current stimulation (tDCS), a low-cost technique that involves placing electrodes on specific s...
What is the current status of trial NCT05598034?
This trial is currently recruiting. It is a NA study. The enrollment target is 144 participants. The study started on 2022-10-20. Estimated completion is 2027-05-01.
What conditions does trial NCT05598034 study?
This clinical trial studies the following conditions: Major Depressive Disorder.
What interventions are being tested in trial NCT05598034?
The interventions under investigation include: Left DLPFC tDCS (DEVICE), Right DLPFC tDCS (DEVICE), Cognitive task (BEHAVIORAL).
Who is sponsoring clinical trial NCT05598034?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05598034 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05598034's enrollment target sits among peer trials
144 106th of 282 higher than 177 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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