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NCT05586451 · ClinicalTrials.gov registry record · NA
Muscle Activation With Acute Bouts of Blood Flow Restricted Resistance Exercise
A NA study, sponsored by Louisiana State University and A&M College.
- Completed
- Registry status
- NA
- Development phase
- 30
- Enrollment target
NCT05586451: Completed NA study, sponsored by Louisiana State University and A&M College.
NCT05586451 is a NA study that has completed, run by Louisiana State University and A&M College. The registered enrollment target is 30 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05586451, a NA study, has completed, sponsored by Louisiana State University and A&M College.
- COMPLETED
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
Study Summary
Blood flow restricted (BFR) resistance exercise has been shown to improve skeletal muscle adaptations to low load resistance exercise. One of many adaptations with resistance training is neural adaptations that occur within the first few weeks of resistance training. It has been hypothesized that these neural adaptations are blunted when using blood flow restricted exercise. Therefore, the investigators propose to examine the muscle activation created by resistance exercise with different intensities with blood flow restriction and without blood flow restriction in sedentary compared to resistance-trained individuals. The investigators will recruit and completely study up to 30, previously untrained and resistance-trained, healthy, college-aged (18-40 years) males. Participants will come in the laboratory for 5 total visits. These visits will consist of a screening/familiarization visit, a strength testing visit, and 3 acute exercise visits. The acute exercise visits will consist of 2 blood flow restricted resistance sessions at different intensities and a traditional high load resistance exercise session. The 3 acute exercise visits will be randomized. The investigators will measure muscle mass (appendicular lean mass) using Dual Energy X-Ray Absorptiometry, muscle strength and endurance using isotonic and isokinetic testing, and muscle activation using surface electromyography. The investigators will also use near infrared spectroscopy (NIRS) to measure the muscle tissue (oxygen) saturation index (TSI) in the vastus lateralis during exercise. Finally, the investigators will also draw blood before and after each exercise session to measure hormones, metabolites, and markers of inflammation using commercially available assays (e.g., ELISAs).
Primary Outcome
Muscle (vastus lateralis) activation will be measured using surface EMG, during the knee extension exercises conducted during the acute HLRE bout.
Interventions
- BEHAVIORAL Traditional High Load Resistance Exercise (HLRE)
- BEHAVIORAL Low Load Resistance Exercise with Blood Flow Restriction (LLBFR)
- BEHAVIORAL Moderate Load Resistance Exercise with Blood Flow Restriction (MLBFR)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2022-07-05 |
| Est. Completion | 2023-08-01 |
| Phase | NA |
What the finished NCT05586451 record still lists
NCT05586451 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 3 interventions - of which Traditional High Load Resistance Exercise (HLRE) is the first listed.
NCT05586451 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05586451 about?
NCT05586451 is a clinical study titled "Muscle Activation With Acute Bouts of Blood Flow Restricted Resistance Exercise". Blood flow restricted (BFR) resistance exercise has been shown to improve skeletal muscle adaptations to low load resistance exercise. One of many adaptations with resistance training is neural adaptations that occur within the first few weeks of resistance training. It has been hypothesized that th...
What is the current status of trial NCT05586451?
This trial is currently completed. It is a NA study. The enrollment target is 30 participants. The study started on 2022-07-05. Estimated completion is 2023-08-01.
What interventions are being tested in trial NCT05586451?
The interventions under investigation include: Traditional High Load Resistance Exercise (HLRE) (BEHAVIORAL), Low Load Resistance Exercise with Blood Flow Restriction (LLBFR) (BEHAVIORAL), Moderate Load Resistance Exercise with Blood Flow Restriction (MLBFR) (BEHAVIORAL).
Who is sponsoring clinical trial NCT05586451?
This trial is sponsored by Louisiana State University and A&M College, which has 7 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05586451's enrollment target sits among peer trials
30 1593rd of 2000 higher than 299 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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