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ACTIVE NOT RECRUITING Phase 3

A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma

NCT05572515 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to compare the efficacy of teclistamab with PVd/Kd in Part 1 and to further characterize safety and efficacy of an alternative dosing for teclistamab in Part 2 in participants with relapsed or refractory multiple myeloma.

Interventions

  • DRUG Teclistamab
  • DRUG Dexamethasone
  • DRUG Pomalidomide
  • DRUG Carfilzomib
  • DRUG Bortezomib

Study Locations (20)

California

  • Alta Bates Comprehensive Cancer Center — Berkeley
  • MemorialCare Long Beach Medical Center — Long Beach
  • University of California Irvine — Orange
  • PIH Health Hospital — Whittier

Florida

  • University of Miami Sylvester Cancer Center — Miami
  • Orlando Health Cancer Institute — Orlando
  • Cleveland Clinic Florida — Weston

Maryland

  • Walter Reed National Military Medical Center — Bethesda
  • Maryland Oncology Hematology P A — Silver Spring

Alaska

  • Alaska Oncology and Hematology LLC — Anchorage

Arizona

  • Banner MD Anderson Cancer Center — Gilbert

Colorado

  • Rocky Mountain Cancer Centers — Aurora

Connecticut

  • University of Connecticut — Farmington

Iowa

  • Mission Cancer Blood — Waukee

Trial Details

FieldValue
Enrollment Target 614 participants
Start Date 2023-03-29
Est. Completion 2031-08-31
Phase Phase 3

Sponsor

Janssen Research & Development

442 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05572515

The ClinicalTrials.gov registry entry for NCT05572515 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 614 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Janssen Research & Development, which has 442 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Relapsed or Refractory Multiple Myeloma appearing as the primary indexed condition, and to 5 interventions — of which Teclistamab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05572515 reports 20 study locations spanning 14 distinct geographic areas — top geographies include California, Florida, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05572515 about?

NCT05572515 is a clinical study titled "A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma". The purpose of this study is to compare the efficacy of teclistamab with PVd/Kd in Part 1 and to further characterize safety and efficacy of an alternative dosing for teclistamab in Part 2 in participants with relapsed or refractory multiple myeloma.

What is the current status of trial NCT05572515?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 614 participants. The study started on 2023-03-29. Estimated completion is 2031-08-31.

What conditions does trial NCT05572515 study?

This clinical trial studies the following conditions: Relapsed or Refractory Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05572515?

The interventions under investigation include: Teclistamab (DRUG), Dexamethasone (DRUG), Pomalidomide (DRUG), Carfilzomib (DRUG), Bortezomib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05572515?

This trial is sponsored by Janssen Research & Development, which has 442 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05572515 being conducted?

This trial has 20 study locations across Alaska, Arizona, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial