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RECRUITING Phase 3

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

NCT05519085 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.

Interventions

  • DRUG Dexamethasone
  • DRUG Pomalidomide
  • DRUG Bortezomib
  • DRUG mezigdomide

Study Locations (20)

Florida

  • Advanced Research — Coral Springs
  • Florida Cancer Specialists - South — Fort Myers
  • Florida Cancer Specialists - North — St. Petersburg
  • Florida Cancer Specialists - East — West Palm Beach

California

  • Cancer and Blood Specialty Clinic — Los Alamitos
  • Sharp Memorial Hospital — San Diego
  • Local Institution - 0273 — West Hollywood

Louisiana

  • Our Lady of the Lake RMC — Baton Rouge
  • Local Institution - 0255 — New Orleans
  • Local Institution - 0385 — Shreveport

Connecticut

  • UConn Health — Farmington
  • Local Institution - 0208 — New Haven

Georgia

  • University Cancer Blood Ctr — Athens
  • Local Institution - 0048 — Marietta

Kansas

  • Local Institution - 0330 — Garden City
  • University of Kansas Medical Center — Westwood

Colorado

  • Local Institution - 0381 — Aurora

Maryland

  • Sinai Hospital Of Baltimore — Baltimore

Trial Details

FieldValue
Enrollment Target 810 participants
Start Date 2022-09-20
Est. Completion 2033-11-30
Phase Phase 3

Sponsor

Celgene

73 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05519085

The ClinicalTrials.gov registry entry for NCT05519085 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 810 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Celgene, which has 73 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Relapsed or Refractory Multiple Myeloma appearing as the primary indexed condition, and to 4 interventions — of which Dexamethasone is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05519085 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Florida, California, Louisiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05519085 about?

NCT05519085 is a clinical study titled "A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)". The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of ther...

What is the current status of trial NCT05519085?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 810 participants. The study started on 2022-09-20. Estimated completion is 2033-11-30.

What conditions does trial NCT05519085 study?

This clinical trial studies the following conditions: Relapsed or Refractory Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05519085?

The interventions under investigation include: Dexamethasone (DRUG), Pomalidomide (DRUG), Bortezomib (DRUG), mezigdomide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05519085?

This trial is sponsored by Celgene, which has 73 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05519085 being conducted?

This trial has 20 study locations across California, Colorado, Connecticut, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial