Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05566431 · ClinicalTrials.gov registry record · NA
Benchmark Evidence Led by Latin America: Trial of Intracranial Pressure - Pediatrics
A NA study of Severe Traumatic Brain Injury, sponsored by University of Washington.
- Recruiting
- Registry status
- NA
- Development phase
- 428
- Enrollment target
- 11
- Study locations
NCT05566431: Recruiting NA study of Severe Traumatic Brain Injury, sponsored by University of Washington.
NCT05566431 is a NA study of Severe Traumatic Brain Injury that is actively recruiting participants, run by University of Washington. The registered enrollment target is 428 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (70% lower). The trial reports 11 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05566431, a NA study of Severe Traumatic Brain Injury, is actively recruiting participants, sponsored by University of Washington.
- RECRUITING
- Registry status
- NA
- Development phase
- 428 participants
- Enrollment target
- 11
- Study locations
Study Summary
Narrative: Worldwide, traumatic brain injury (TBI) is a leading cause of death and disability among children and adolescents. The Investigators aim to test whether pediatric TBI treatment guided by invasive intracranial pressure monitoring produces better patient outcomes than care guided by a protocol without invasive monitoring. Study findings will inform clinical practice in treating pediatric severe TBI globally. Focused didactic and experience-based learning opportunities will increase the research capacity of pediatric intensivists in Latin America.
Primary Outcome
PedsQL is a generic, health-related quality of life instrument developed to measure the core dimensions of physical, cognitive, mental, social health, and role (school) function. Minimum and maximum values: 0-100. Higher scores have better outcomes.
Conditions Studied
Interventions
- OTHER ICP
- OTHER CREVICE
Study Locations (11)
Other
- Fundación Hospital de la Misericordia - Bogotá
- Hospital Fundacion Amigos de la Salud - Montería
- Hospital de Niños Benjamín Bloom - San Salvador
- Hospital Regional de Esquintla - Escuintla
- Hospital General San Juan de Dios - Guatemala City
- Hospital Regional de Occidente San Juan de Dios - Quetzaltenango
- Hospital Escuela - Tegucigalpa
- Hospital de Emergencias Pediátricas - Lima
- Hospital Edgardo Rebagliati Martins - Lima
- Instituto Nacional de Salud del Niño - San Borja - Lima
Washington
- University of Washington, Harborview Medical Center - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 428 participants |
| Start Date | 2023-03-22 |
| Est. Completion | 2028-01-31 |
| Phase | NA |
What NCT05566431 shows while recruiting
NCT05566431 is an interventional study that assigns participants to a tested intervention. The registered 428 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (70% lower).
The record links to 1 condition, with Severe Traumatic Brain Injury appearing as the primary indexed condition, and to 2 interventions - of which ICP is the first listed.
NCT05566431 lists 11 locations in 2 states (Other, Washington).
Frequently Asked Questions
What is clinical trial NCT05566431 about?
NCT05566431 is a clinical study titled "Benchmark Evidence Led by Latin America: Trial of Intracranial Pressure - Pediatrics". Narrative: Worldwide, traumatic brain injury (TBI) is a leading cause of death and disability among children and adolescents. The Investigators aim to test whether pediatric TBI treatment guided by invasive intracranial pressure monitoring produces better patient outcomes than care guided by a prot...
What is the current status of trial NCT05566431?
This trial is currently recruiting. It is a NA study. The enrollment target is 428 participants. The study started on 2023-03-22. Estimated completion is 2028-01-31.
What conditions does trial NCT05566431 study?
This clinical trial studies the following conditions: Severe Traumatic Brain Injury.
What interventions are being tested in trial NCT05566431?
The interventions under investigation include: ICP (OTHER), CREVICE (OTHER).
Who is sponsoring clinical trial NCT05566431?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05566431 being conducted?
This trial has 11 study locations across Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Severe Traumatic Brain Injury
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05566431's enrollment target sits among peer trials
428 236th of 2000 higher than 1,765 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT05646316 · 428 participants · Phase 3
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer
- NCT05797610 · 428 participants · Phase 3
A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression
- NCT06073626 · 428 participants · NA
Addressing Genomic Disparities in Cancer Survivors
- NCT06947538 · 428 participants · NA
Stepped Care for Posttraumatic Stress Disorder Study
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI