Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
NCT05552222 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to compare the efficacy of teclistamab in combination with daratumumab and lenalidomide (Tec-DR) and talquetamab in combination with daratumumab and lenalidomide (Tal-DR) versus daratumumab, lenalidomide, dexamethasone (DRd).
Conditions Studied
Interventions
- DRUG Teclistamab
- DRUG Dexamethasone
- DRUG Lenalidomide
- DRUG Daratumumab
- DRUG Talquetamab
Study Locations (20)
California
- UCSF Fresno — Clovis
- City of Hope Duarte — Duarte
- City of Hope Orange County Lennar Foundation Cancer Center — Irvine
- Cancer and Blood Specialty Clinic — Los Alamitos
- Valkyrie Clinical Trials — Los Angeles
Arizona
- Banner MD Anderson Cancer Center — Gilbert
- University of Arizona Cancer Center — Tucson
Connecticut
- University of Connecticut — Farmington
- Yale New Haven Hospital — New Haven
Florida
- AdventHealth Medical Group Blood & Marrow Transplant at Orlando — Orlando
- Cleveland Clinic Florida — Weston
Maryland
- Johns Hopkins University School of Medicine JHUSOM — Baltimore
- Center for Cancer and Blood Disorders — Bethesda
Delaware
- ChristianaCare Helen F Graham Cancer Center and Research Institute — Newark
Georgia
- City of Hope Cancer Center — Newnan
Illinois
- University Of Illinois Medical Center — Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,590 participants |
| Start Date | 2022-10-25 |
| Est. Completion | 2033-10-28 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05552222
The ClinicalTrials.gov registry entry for NCT05552222 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,590 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Janssen Research & Development, which has 442 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 5 interventions — of which Teclistamab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05552222 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Arizona, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05552222 about?
NCT05552222 is a clinical study titled "A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma". The purpose of this study is to compare the efficacy of teclistamab in combination with daratumumab and lenalidomide (Tec-DR) and talquetamab in combination with daratumumab and lenalidomide (Tal-DR) versus daratumumab, lenalidomide, dexamethasone (DRd).
What is the current status of trial NCT05552222?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 1,590 participants. The study started on 2022-10-25. Estimated completion is 2033-10-28.
What conditions does trial NCT05552222 study?
This clinical trial studies the following conditions: Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05552222?
The interventions under investigation include: Teclistamab (DRUG), Dexamethasone (DRUG), Lenalidomide (DRUG), Daratumumab (DRUG), Talquetamab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05552222?
This trial is sponsored by Janssen Research & Development, which has 442 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05552222 being conducted?
This trial has 20 study locations across Arizona, California, Connecticut, Delaware, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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