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NCT05547542 · ClinicalTrials.gov registry record · Phase 1
Positron Emission Tomography (PET) Trial to Evaluate Target Occupancy of CVL-354 at Kappa and Mu Opioid Receptors in Brain Following Oral Dosing
A Phase 1 study, sponsored by Cerevel Therapeutics.
- Completed
- Registry status
- Phase 1
- Development phase
- 19
- Enrollment target
NCT05547542: Completed Phase 1 study, sponsored by Cerevel Therapeutics.
NCT05547542 is a Phase 1 study that has completed, run by Cerevel Therapeutics. The registered enrollment target is 19 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (68% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05547542, a Phase 1 study, has completed, sponsored by Cerevel Therapeutics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 19 participants
- Enrollment target
Study Summary
The primary purpose of this study is to assess the target occupancy at kappa and mu opioid receptors in the brain after single oral doses of CVL-354 in healthy adult participants.
Interventions
- DRUG CVL-354
- DRUG [11C]-LY2795050
- DRUG [11C]-carfentanil
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 19 participants |
| Start Date | 2023-03-02 |
| Est. Completion | 2024-08-06 |
| Phase | Phase 1 |
What the finished NCT05547542 record still lists
NCT05547542 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 19 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (68% lower).
The record links to 0 conditions, and to 3 interventions - of which CVL-354 is the first listed.
NCT05547542 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05547542 about?
NCT05547542 is a clinical study titled "Positron Emission Tomography (PET) Trial to Evaluate Target Occupancy of CVL-354 at Kappa and Mu Opioid Receptors in Brain Following Oral Dosing". The primary purpose of this study is to assess the target occupancy at kappa and mu opioid receptors in the brain after single oral doses of CVL-354 in healthy adult participants.
What is the current status of trial NCT05547542?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 19 participants. The study started on 2023-03-02. Estimated completion is 2024-08-06.
What interventions are being tested in trial NCT05547542?
The interventions under investigation include: CVL-354 (DRUG), [11C]-LY2795050 (DRUG), [11C]-carfentanil (DRUG).
Who is sponsoring clinical trial NCT05547542?
This trial is sponsored by Cerevel Therapeutics, which has 21 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05547542's enrollment target sits among peer trials
19 1716th of 2000 higher than 281 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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