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NCT05546515 · ClinicalTrials.gov registry record · Phase 2
Suvorexant for Opioid/Stimulant Co-use
A Phase 2 study, sponsored by Johns Hopkins University.
- Completed
- Registry status
- Phase 2
- Development phase
- 20
- Enrollment target
NCT05546515: Completed Phase 2 study, sponsored by Johns Hopkins University.
NCT05546515 is a Phase 2 study that has completed, run by Johns Hopkins University. The registered enrollment target is 20 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (85% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05546515, a Phase 2 study, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 20 participants
- Enrollment target
Study Summary
This study will evaluate whether Suvorexant 20mg reduces drug use and craving, and improves sleep and stress among persons with co-occurring opioid use disorder and stimulant use disorder.
Primary Outcome
Opioid use (measured via uranalysis for qualitative opioid assay) other than prescribed methadone or buprenorphine at scheduled study visits up to 30 days post-randomization (yes vs. no)
Interventions
- DRUG Placebo
- DRUG Suvorexant (dual orexin receptor antagonist)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2022-12-01 |
| Est. Completion | 2024-11-30 |
| Phase | Phase 2 |
What the finished NCT05546515 record still lists
NCT05546515 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (85% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT05546515 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05546515 about?
NCT05546515 is a clinical study titled "Suvorexant for Opioid/Stimulant Co-use". This study will evaluate whether Suvorexant 20mg reduces drug use and craving, and improves sleep and stress among persons with co-occurring opioid use disorder and stimulant use disorder.
What is the current status of trial NCT05546515?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2022-12-01. Estimated completion is 2024-11-30.
What interventions are being tested in trial NCT05546515?
The interventions under investigation include: Placebo (DRUG), Suvorexant (dual orexin receptor antagonist) (DRUG).
Who is sponsoring clinical trial NCT05546515?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05546515's enrollment target sits among peer trials
20 1805th of 2000 higher than 107 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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