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NCT05542238 · ClinicalTrials.gov registry record · NA
The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury
A NA study, sponsored by State University of New York at Buffalo.
- Terminated
- Registry status
- NA
- Development phase
- 6
- Enrollment target
NCT05542238: Clinical Trial NA study, sponsored by State University of New York at Buffalo.
NCT05542238 is a NA study that was terminated before completion, run by State University of New York at Buffalo. The registered enrollment target is 6 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05542238, a NA study, was terminated before completion, sponsored by State University of New York at Buffalo.
- TERMINATED
- Registry status
- NA
- Development phase
- 6 participants
- Enrollment target
Study Summary
The aims of this proposal are to: 1) investigate whether individuals with spinal cord injury (SCI) demonstrate cardiac autonomic, cerebrovascular, and cognitive dysfunctions compared to non-injured age- and sex-matched controls in the following conditions: supine rest and head-up tilt/face-cooling test; 2) examine if autonomic completeness/ incompleteness, physical activity, and psychological distress are predictors for dysfunctions during supine rest and head-up tilt/face cooling conditions in SCI individuals; 3) examine if one bout of moderate-intensity aerobic exercise temporarily improves cardiac autonomic and cerebrovascular functions and thereby improves cognition when in supine rest and head- up tilt/face cooling conditions. The study will include an initial visit and an experimental visit to our lab. Three groups of participants will be included in this study: Group 1, SCI with acute exercise; group 2, SCI with rest-control; and group 3, age- and sex-matched non-injured individuals. Cardiovascular variables, such as heart rate variability, blood pressure variability, and cerebrovascular variables, such as cerebral blood flow velocity and oxygenated hemoglobin, and cognitive performance will be examined. The investigator hypothesizes that individuals with SCI will have impaired cardiac autonomic, cerebrovascular, and cognitive functions compared to the non-injured controls, and an acute exercise can improve those functions. Autonomic completeness/incompleteness, physical activity, and psychological distress are significant factors that predict cardiac autonomic, cerebrovascular, and cognitive functions in individuals with SCI.
Primary Outcome
Low frequency component of blood pressure variability in mmHg\^2
Interventions
- BEHAVIORAL One bout of moderate-intensity sub-maximal aerobic exercise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6 participants |
| Start Date | 2022-09-06 |
| Est. Completion | 2024-12-18 |
| Phase | NA |
Why NCT05542238 stopped before completion
NCT05542238 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 6 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 1 intervention - of which One bout of moderate-intensity sub-maximal aerobic exercise is the first listed.
NCT05542238 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05542238 about?
NCT05542238 is a clinical study titled "The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury". The aims of this proposal are to: 1) investigate whether individuals with spinal cord injury (SCI) demonstrate cardiac autonomic, cerebrovascular, and cognitive dysfunctions compared to non-injured age- and sex-matched controls in the following conditions: supine rest and head-up tilt/face-cooling t...
What is the current status of trial NCT05542238?
This trial is currently terminated. It is a NA study. The enrollment target is 6 participants. The study started on 2022-09-06. Estimated completion is 2024-12-18.
What interventions are being tested in trial NCT05542238?
The interventions under investigation include: One bout of moderate-intensity sub-maximal aerobic exercise (BEHAVIORAL).
Who is sponsoring clinical trial NCT05542238?
This trial is sponsored by State University of New York at Buffalo, which has 243 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05542238's enrollment target sits among peer trials
6 1983rd of 2000 higher than 13 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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