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NCT05512585 · ClinicalTrials.gov registry record · NA
A Physiological Study to Assess Awake Prone Positioning and Respiratory Support in Healthy Volunteers
A NA study, sponsored by Rush University Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT05512585: Completed NA study, sponsored by Rush University Medical Center.
NCT05512585 is a NA study that has completed, run by Rush University Medical Center. The registered enrollment target is 20 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05512585, a NA study, has completed, sponsored by Rush University Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
Awake prone positioning (APP) has been proven to reduce the intubation rate for patients with COVID-19-induced hypoxemic respiratory failure. Our recent meta-analysis found APP was only effective for patients who were treated by high-flow nasal cannula (HFNC), not for patients using conventional oxygen therapy (COT).In a recent multicenter RCT, Perkins and colleagues reported that continuous positive airway pressure (CPAP) was superior to HFNC and conventional oxygen therapy in reducing intubation rate. Thus, it is essential to evaluate the physiological mechanism of APP under different respiratory supports, such as COT, HFNC, or CPAP. We hypothesize that HFNC or CPAP is more effective when combined with APP than COT combined with APP. Electrical impedance tomography (EIT imaging) has been broadly utilized to assess patient ventilation homogeneity and respiratory volume monitor (RVM) has been used to evaluate patient's tidal volumes breath-by-breath. In this study, 20 healthy volunteers will use different respiratory support devices (HFNC, CPAP, and COT) in different settings and their combinations withAPP in a random sequence, assessed by EIT and RVM.
Primary Outcome
Regional ventilation assessed by regional tidal impedance variations relative to global tidal impedance variation (ΔzROI/Δzglobal) obtained by electrical impedance tomography (EIT)
Interventions
- OTHER awake prone positioning with advanced respiratory support (high-flow nasal cannula or continuous positive airway pressure)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2022-08-28 |
| Est. Completion | 2022-11-27 |
| Phase | NA |
What the finished NCT05512585 record still lists
NCT05512585 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which awake prone positioning with advanced respiratory support (high-flow nasal cannula or continuous positive airway pressure) is the first listed.
NCT05512585 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05512585 about?
NCT05512585 is a clinical study titled "A Physiological Study to Assess Awake Prone Positioning and Respiratory Support in Healthy Volunteers". Awake prone positioning (APP) has been proven to reduce the intubation rate for patients with COVID-19-induced hypoxemic respiratory failure. Our recent meta-analysis found APP was only effective for patients who were treated by high-flow nasal cannula (HFNC), not for patients using conventional oxy...
What is the current status of trial NCT05512585?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2022-08-28. Estimated completion is 2022-11-27.
What interventions are being tested in trial NCT05512585?
The interventions under investigation include: awake prone positioning with advanced respiratory support (high-flow nasal cannula or continuous positive airway pressure) (OTHER).
Who is sponsoring clinical trial NCT05512585?
This trial is sponsored by Rush University Medical Center, which has 320 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05512585's enrollment target sits among peer trials
20 1768th of 2000 higher than 140 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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