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NCT05487664 · ClinicalTrials.gov registry record · NA
RM1 Project 2 - tAN fMRI
A NA study of Auricular Stimulation, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- NA
- Development phase
- 96
- Enrollment target
- 1
- Study location
NCT05487664: Recruiting NA study of Auricular Stimulation, sponsored by Medical University of South Carolina.
NCT05487664 is a NA study of Auricular Stimulation that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 96 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05487664, a NA study of Auricular Stimulation, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- NA
- Development phase
- 96 participants
- Enrollment target
- 1
- Study location
Study Summary
In this one-visit, randomized, double-blind, sham-controlled trial, we plan to use a novel concurrent transcutaneous auricular neurostimulation (tAN) paradigm during functional magnetic resonance imaging (fMRI) paradigm in 96 individuals to determine whether tAN administered to two cranial nerves simultaneously produces greater neurophysiologic effects than stimulating solely to the auricular branch of the vagus nerve (ABVN) or the auriculotemporal nerve (ATN; branch of trigeminal nerve) alone. Within the MRI scanner, each participant will be connected to a series of electrodes that stimulate 4 targets (ABVN only, ATN only, ABVN plus ATN, and Sham).
Primary Outcome
. tAN will will be administered to participants within the bore of the MRI scanner while we acquire high resolution functional neuroimaging. Both a general linear model and SNM approach will be used to examine BOLD signal changes during stimulation relative to rest blocks, comparing each of the four stimulation targets within- and between subjects to determine whether stimulating two cranial nerves produces a more robust neurophysiological effect than either single nerve or sham stimulation alon
Conditions Studied
Interventions
- DEVICE Transcutaneous Auricular Neruostimulation (tAN)
Study Locations (1)
South Carolina
- Medical University of South Carolina Institute of Psychiatry - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 96 participants |
| Start Date | 2023-03-17 |
| Est. Completion | 2027-10-01 |
| Phase | NA |
What NCT05487664 shows while recruiting
NCT05487664 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 96 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower).
The record links to 1 condition, with Auricular Stimulation appearing as the primary indexed condition, and to 1 intervention - of which Transcutaneous Auricular Neruostimulation (tAN) is the first listed.
NCT05487664 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT05487664 about?
NCT05487664 is a clinical study titled "RM1 Project 2 - tAN fMRI". In this one-visit, randomized, double-blind, sham-controlled trial, we plan to use a novel concurrent transcutaneous auricular neurostimulation (tAN) paradigm during functional magnetic resonance imaging (fMRI) paradigm in 96 individuals to determine whether tAN administered to two cranial nerves si...
What is the current status of trial NCT05487664?
This trial is currently recruiting. It is a NA study. The enrollment target is 96 participants. The study started on 2023-03-17. Estimated completion is 2027-10-01.
What conditions does trial NCT05487664 study?
This clinical trial studies the following conditions: Auricular Stimulation.
What interventions are being tested in trial NCT05487664?
The interventions under investigation include: Transcutaneous Auricular Neruostimulation (tAN) (DEVICE).
Who is sponsoring clinical trial NCT05487664?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05487664 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05487664's enrollment target sits among peer trials
96 925th of 2000 higher than 1,070 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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