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NCT05484622 · ClinicalTrials.gov registry record · Phase 1
Study of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive IDH-1 Mutant Glioma
A Phase 1 study of Astrocytoma and Oligodendroglioma, sponsored by Institut de Recherches Internationales Servier.
- Active
- Registry status
- Phase 1
- Development phase
- 60
- Enrollment target
- 17
- Study locations
NCT05484622: Active Phase 1 study of Astrocytoma and Oligodendroglioma, sponsored by Institut de Recherches Internationales Servier.
NCT05484622 is a Phase 1 study of Astrocytoma and Oligodendroglioma that is active but no longer recruiting, run by Institut de Recherches Internationales Servier. The registered enrollment target is 60 participants, above the 46-participant average among 19 other Astrocytoma trials with a reported enrollment target (30% higher). The trial reports 17 study locations across 14 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05484622, a Phase 1 study of Astrocytoma and Oligodendroglioma, is active but no longer recruiting, sponsored by Institut de Recherches Internationales Servier.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 60 participants
- Enrollment target
- 17
- Study locations
Study Summary
Vorasidenib in combination with pembrolizumab in participants with recurrent or progressive isocitrate dehydrogenase-1 (IDH-1) mutant Glioma.
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG Vorasidenib
Study Locations (17)
California
- University of California, Los Angeles (Site: 840113) - Los Angeles
- University of California, San Francisco (Site: 840149) - San Francisco
Massachusetts
- Massachusetts General Hospital (Site: 840104) - Boston
- Dana-Farber Cancer Institute (Site: 840139) - Boston
Ohio
- Cleveland Clinic - Cleveland
- Mayo Clinic Florida - Cleveland
Alabama
- University of Alabama at Birmingham - Birmingham
Colorado
- University of Colorado - Aurora
Florida
- University of Miami (Site: 840129) - Miami
Illinois
- Northwestern University (Site: 840123) - Chicago
Maryland
- Johns Hopkins University - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2023-01-20 |
| Est. Completion | 2027-08-30 |
| Phase | Phase 1 |
What the registry record for NCT05484622 still lists
NCT05484622 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, above the 46-participant average among 19 other Astrocytoma trials with a reported enrollment target (30% higher).
The record links to 2 conditions, with Astrocytoma appearing as the primary indexed condition, and to 2 interventions - of which Pembrolizumab is the first listed.
NCT05484622 lists 17 locations in 14 states (California, Massachusetts, Ohio).
Frequently Asked Questions
What is clinical trial NCT05484622 about?
NCT05484622 is a clinical study titled "Study of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive IDH-1 Mutant Glioma". Vorasidenib in combination with pembrolizumab in participants with recurrent or progressive isocitrate dehydrogenase-1 (IDH-1) mutant Glioma.
What is the current status of trial NCT05484622?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2023-01-20. Estimated completion is 2027-08-30.
What conditions does trial NCT05484622 study?
This clinical trial studies the following conditions: Astrocytoma, Oligodendroglioma.
What interventions are being tested in trial NCT05484622?
The interventions under investigation include: Pembrolizumab (DRUG), Vorasidenib (DRUG).
Who is sponsoring clinical trial NCT05484622?
This trial is sponsored by Institut de Recherches Internationales Servier, which has 27 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05484622 being conducted?
This trial has 17 study locations across Alabama, California, Colorado, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05484622's enrollment target sits among peer trials
60 5th of 19 higher than 13 of 19 other Astrocytoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Astrocytoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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