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NCT05464758 · ClinicalTrials.gov registry record · NA
The Effects of Cold Adaptation on Skin Blood Flow, Hand Function, and Comfort in Healthy Adults
A NA study, sponsored by United States Army Research Institute of Environmental Medicine.
- Completed
- Registry status
- NA
- Development phase
- 16
- Enrollment target
NCT05464758: Completed NA study, sponsored by United States Army Research Institute of Environmental Medicine.
NCT05464758 is a NA study that has completed, run by United States Army Research Institute of Environmental Medicine. The registered enrollment target is 16 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05464758, a NA study, has completed, sponsored by United States Army Research Institute of Environmental Medicine.
- COMPLETED
- Registry status
- NA
- Development phase
- 16 participants
- Enrollment target
Study Summary
In cold weather environments, blood flow to the extremities is significantly reduced, which severely impairs hand function and induces thermal discomfort. Prolonged or repeated cold exposure elicits an adaptive habituation response that is characterized by blunted skin vasoconstriction and thus may be an effective strategy to improve peripheral perfusion, reduce thermal discomfort, and maintain hand function during cold weather military operations. Since mission conditions often involve low ambient temperatures, countermeasures that reduce cold-induced decrements in hand function and thermal comfort are important to enhance Warfighter readiness in cold weather battlefield environments. The goals of this study are to 1) evaluate the effectiveness of cold habituation in improving skin blood flow, hand function, and thermal comfort during cold exposure and 2) identify the mechanisms that contribute to improvements in skin blood flow following habituation.
Primary Outcome
Skin blood flow will be measured using non-invasive laser-Doppler flowmetry probes before and during cold exposure. Output (red blood cell flux) will be divided by mean arterial blood pressure to give an index of cutaneous vascular conductance \[CVC, flux/mmHg\].
Interventions
- OTHER Repeated cold exposure
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2022-08-01 |
| Est. Completion | 2024-09-13 |
| Phase | NA |
What the finished NCT05464758 record still lists
NCT05464758 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which Repeated cold exposure is the first listed.
NCT05464758 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05464758 about?
NCT05464758 is a clinical study titled "The Effects of Cold Adaptation on Skin Blood Flow, Hand Function, and Comfort in Healthy Adults". In cold weather environments, blood flow to the extremities is significantly reduced, which severely impairs hand function and induces thermal discomfort. Prolonged or repeated cold exposure elicits an adaptive habituation response that is characterized by blunted skin vasoconstriction and thus may ...
What is the current status of trial NCT05464758?
This trial is currently completed. It is a NA study. The enrollment target is 16 participants. The study started on 2022-08-01. Estimated completion is 2024-09-13.
What interventions are being tested in trial NCT05464758?
The interventions under investigation include: Repeated cold exposure (OTHER).
Who is sponsoring clinical trial NCT05464758?
This trial is sponsored by United States Army Research Institute of Environmental Medicine, which has 59 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05464758's enrollment target sits among peer trials
16 1871st of 2000 higher than 120 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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