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Multiple Rising Dose Study of MK-6194 in Participants With Atopic Dermatitis (MK-6194-008)
NCT05450198 · View on ClinicalTrials.gov ↗
Study Summary
The primary objective of this study is to characterize the safety and tolerability of MK-6194 following multiple doses among participants with moderate to severe atopic dermatitis who are unresponsive to other therapies.
Conditions Studied
Interventions
- BIOLOGICAL Placebo
- BIOLOGICAL MK-6194
Study Locations (19)
Florida
- Miami Dermatology and Laser Research ( Site 0025) — Miami
- Global Health Research Center, Inc. ( Site 0005) — Miami Lakes
- Genesis Clinical Research, LLC ( Site 0004) — Tampa
- ForCare Clinical Research ( Site 0003) — Tampa
Texas
- North Texas Center for Clinical Research ( Site 0028) — Frisco
- Progressive Clinical Research ( Site 0022) — San Antonio
- Complete Dermatology ( Site 0023) — Sugar Land
Arkansas
- Arkansas Research Trials-Clinical Trials ( Site 0002) — North Little Rock
Georgia
- Advanced Medical Research, PC. ( Site 0027) — Sandy Springs
Minnesota
- AXIS Clinicals ( Site 0029) — Dilworth
Ohio
- Remington Davis Clinical Research ( Site 0021) — Columbus
Pennsylvania
- Paddington Testing Company ( Site 0010) — Philadelphia
Washington
- Premier Clinical Research ( Site 0026) — Spokane
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 72 participants |
| Start Date | 2022-08-08 |
| Est. Completion | 2024-05-22 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05450198
The ClinicalTrials.gov registry entry for NCT05450198 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 72 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Dermatitis, Atopic appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05450198 reports 19 study locations spanning 14 distinct geographic areas — top geographies include Florida, Texas, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05450198 about?
NCT05450198 is a clinical study titled "Multiple Rising Dose Study of MK-6194 in Participants With Atopic Dermatitis (MK-6194-008)". The primary objective of this study is to characterize the safety and tolerability of MK-6194 following multiple doses among participants with moderate to severe atopic dermatitis who are unresponsive to other therapies.
What is the current status of trial NCT05450198?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 72 participants. The study started on 2022-08-08. Estimated completion is 2024-05-22.
What conditions does trial NCT05450198 study?
This clinical trial studies the following conditions: Dermatitis, Atopic. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05450198?
The interventions under investigation include: Placebo (BIOLOGICAL), MK-6194 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05450198?
This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05450198 being conducted?
This trial has 19 study locations across Arkansas, Florida, Georgia, Minnesota, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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