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NCT05447559 · ClinicalTrials.gov registry record · Phase 4
Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study
A Phase 4 study, sponsored by Monash University.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 9,180
- Enrollment target
NCT05447559: Recruiting Phase 4 study, sponsored by Monash University.
NCT05447559 is a Phase 4 study that is actively recruiting participants, run by Monash University. The registered enrollment target is 9,180 participants, above the 517-participant average among 9,235 other Phase 4 trials with a reported enrollment target (1676% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05447559, a Phase 4 study, is actively recruiting participants, sponsored by Monash University.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 9,180 participants
- Enrollment target
Study Summary
This multicentre, adaptive, pragmatic, double-blind, three-arm, placebo-controlled, randomised, non-inferiority clinical trial will compare the incidence of surgical site infection and other healthcare associated infections, health economic and microbiological impact after intraoperative only (Arm A), to 24 hours (Arm B) and, to 48 hours (Arm C) of IV cefazolin and placebo postoperative surgical antimicrobial prophylaxis in patients undergoing cardiac surgery
Primary Outcome
Surgical site infection according to CDC / NHSN definition
Interventions
- DRUG Cefazolin
- DRUG Water for injection
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9,180 participants |
| Start Date | 2023-02-07 |
| Est. Completion | 2028-06 |
| Phase | Phase 4 |
What NCT05447559 shows while recruiting
NCT05447559 is an interventional study that assigns participants to a tested intervention. Its 9,180 participants enrollment target places it among the larger protocols in the corpus, above the 517-participant average among 9,235 other Phase 4 trials with a reported enrollment target (1676% higher).
The record links to 0 conditions, and to 2 interventions - of which Cefazolin is the first listed.
NCT05447559 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05447559 about?
NCT05447559 is a clinical study titled "Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study". This multicentre, adaptive, pragmatic, double-blind, three-arm, placebo-controlled, randomised, non-inferiority clinical trial will compare the incidence of surgical site infection and other healthcare associated infections, health economic and microbiological impact after intraoperative only (Arm A...
What is the current status of trial NCT05447559?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 9,180 participants. The study started on 2023-02-07. Estimated completion is 2028-06.
What interventions are being tested in trial NCT05447559?
The interventions under investigation include: Cefazolin (DRUG), Water for injection (DRUG).
Who is sponsoring clinical trial NCT05447559?
This trial is sponsored by Monash University, which has 2 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05447559's enrollment target sits among peer trials
9,180 9th of 2000 higher than 1,992 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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