Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05436392 · ClinicalTrials.gov registry record · NA
De-adopting Routine Preoperative Benzodiazepines for Older Surgical Patients
A NA study, sponsored by University of Pennsylvania.
- Completed
- Registry status
- NA
- Development phase
- 517,611
- Enrollment target
NCT05436392: Completed NA study, sponsored by University of Pennsylvania.
NCT05436392 is a NA study that has completed, run by University of Pennsylvania. The registered enrollment target is 517,611 participants, above the 1,395-participant average among 58,714 other NA trials with a reported enrollment target (37005% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05436392, a NA study, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- NA
- Development phase
- 517,611 participants
- Enrollment target
Study Summary
Over 21 million surgical procedures take place among adults aged 65 and older in the US each year, and most older surgical patients in the US now receive benzodiazepines (e.g., midazolam, lorazepam) during anesthesia care. This occurs despite recommendations to avoid these medications in older patients due to associated medical risks and lack of demonstrated benefit. In other words, routine benzodiazepine administration to older surgical patients is likely to represent low-value care that is a suitable target for de-adoption. In this study, we will evaluate a United States Anesthesia Partners (USAP, Dallas, TX) quality improvement initiative using peer comparison feedback to clinicians and/or mailed informational letters to patients as strategies to encourage physician de-adoption of routine preoperative benzodiazepine administration to older surgical patients. In partnership with USAP, this study will be conducted using randomization to evaluate its effect.
Primary Outcome
The primary outcome measure is the change in the rate of benzodiazepine administration among eligible surgical cases.
Interventions
- BEHAVIORAL Peer Comparison Feedback
- BEHAVIORAL Patient Informational Letter
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 517,611 participants |
| Start Date | 2022-08-08 |
| Est. Completion | 2023-12-31 |
| Phase | NA |
What the finished NCT05436392 record still lists
NCT05436392 is an interventional study that assigns participants to a tested intervention. Its 517,611 participants enrollment target places it among the larger protocols in the corpus, above the 1,395-participant average among 58,714 other NA trials with a reported enrollment target (37005% higher).
The record links to 0 conditions, and to 2 interventions - of which Peer Comparison Feedback is the first listed.
NCT05436392 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05436392 about?
NCT05436392 is a clinical study titled "De-adopting Routine Preoperative Benzodiazepines for Older Surgical Patients". Over 21 million surgical procedures take place among adults aged 65 and older in the US each year, and most older surgical patients in the US now receive benzodiazepines (e.g., midazolam, lorazepam) during anesthesia care. This occurs despite recommendations to avoid these medications in older patie...
What is the current status of trial NCT05436392?
This trial is currently completed. It is a NA study. The enrollment target is 517,611 participants. The study started on 2022-08-08. Estimated completion is 2023-12-31.
What interventions are being tested in trial NCT05436392?
The interventions under investigation include: Peer Comparison Feedback (BEHAVIORAL), Patient Informational Letter (BEHAVIORAL).
Who is sponsoring clinical trial NCT05436392?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05436392's enrollment target sits among peer trials
517,611 1st of 2000 higher than 2,000 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT05065060 · 500,000 participants
Parkinson Progression Marker Initiative Online (PPMI Online)
- NCT06017687 · 500,000 participants · NA
Data Collection and Evaluation of OptiBP Under Investigational Use
- NCT06342375 · 425,000 participants · NA
Enrollment Barriers, Procedural Denials, and Loss of Medicaid Coverage
- NCT06934239 · 400,000 participants · Phase 4
A Trial Comparing Screening Mammography With and Without Assistance From Artificial Intelligence for Breast Cancer Detection and Recall Rates in Adult Patients
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI