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NCT05422469 · ClinicalTrials.gov registry record · NA
Neurobehavioral Investigations of Approach Dynamics in the Ventral Striatum
A NA study, sponsored by Baylor College of Medicine.
- Not yet
- Registry status
- NA
- Development phase
- 12
- Enrollment target
NCT05422469 is a NA study that has not yet begun recruiting, run by Baylor College of Medicine. The registered enrollment target is 12 participants.
The verdict
NCT05422469, a NA study, has not yet begun recruiting, sponsored by Baylor College of Medicine.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 12 participants
- Enrollment target
Study Summary
Traditional strategies for diagnosing psychiatric disorders focus on definitions based on constellations of co-occurring symptoms. Tracking symptom severity across therapy arcs relies on administering scales that again ask questions about symptoms. These strategies have allowed some degree of standardization but suffer from having a phenomenological rather than mechanistic foundation (in terms of diagnosis) as well as subjectivity and temporal sparseness (in terms of measurement). The investigators apply a transdiagnostic framework based on the neurobiological concept of approach behavior. Several psychiatric disorders (including OCD, uni- and bipolar depression, PTSD and anxiety disorders, and addiction disorders) are characterized by dysfunction in approach behavior. The investigators study the neurobehavioral basis of approach dysfunction in a cohort of individuals with severe OCD and bipolar disorder (BD). To study these behaviors, the investigators deploy a suite of wearables and peripherals (Oura ring, Apple Watch, iPhone, audioband) that allow continuous and dense measurement of behaviors relevant to the approach hypothesis: socialization, activity, and sleep patterns. The investigators perform these measurements in two selected environments. One is a novel apartment-style setting (neurobehavioral unit, NBU) that combines the high-bandwidth data acquisition capability of a lab with the naturalistic relevance and comfort of the home. The second is the truly natural and maximally ethologically relevant setting of the ambulatory "home" environment in which people spend the majority of their time. The participants will be individuals planned for deep brain stimulation (DBS) implant for their OCD or BD. The bi-directional (stimulate as well as record) nature of the DBS systems will allow neural recordings that the investigators will synchronize with the behavioral data streams. The investigators will apply predictive computational models in conjunction with the
Interventions
- DEVICE Medtronic Percept RC neurostimulator
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2026-08 |
| Est. Completion | 2029-08 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05422469
The ClinicalTrials.gov registry entry for NCT05422469 describes a study currently listed as not yet recruiting, categorized as NA. The registered enrollment target is 12 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Baylor College of Medicine, which has 616 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Medtronic Percept RC neurostimulator is the first listed.
NCT05422469 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT05422469 about?
NCT05422469 is a clinical study titled "Neurobehavioral Investigations of Approach Dynamics in the Ventral Striatum". Traditional strategies for diagnosing psychiatric disorders focus on definitions based on constellations of co-occurring symptoms. Tracking symptom severity across therapy arcs relies on administering scales that again ask questions about symptoms. These strategies have allowed some degree of standa...
What is the current status of trial NCT05422469?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 12 participants. The study started on 2026-08. Estimated completion is 2029-08.
What interventions are being tested in trial NCT05422469?
The interventions under investigation include: Medtronic Percept RC neurostimulator (DEVICE).
Who is sponsoring clinical trial NCT05422469?
This trial is sponsored by Baylor College of Medicine, which has 616 total clinical trials registered on ClinicalTrials.gov.
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