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NCT05418582 · ClinicalTrials.gov registry record · Phase 1
Drug-drug Interactions Between DZD9008 and Itraconazole/Carbamazepine
A Phase 1 study, sponsored by Dizal Pharmaceuticals.
- Completed
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
NCT05418582: Completed Phase 1 study, sponsored by Dizal Pharmaceuticals.
NCT05418582 is a Phase 1 study that has completed, run by Dizal Pharmaceuticals. The registered enrollment target is 40 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (33% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05418582, a Phase 1 study, has completed, sponsored by Dizal Pharmaceuticals.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
Study Summary
This is a Phase 1, single-center, nonrandomized, open-label, 2-part, fixed-sequence, drug-drug interaction (DDI) study to assess the effect of multiple doses of itraconazole, a CYP3A4 enzyme inhibitor, on the single dose PK of DZD9008 in healthy adult subjects (Part A) and to assess the effect of multiple doses of carbamazepine, a CYP3A4 inducer, on the single dose PK of DZD9008 in healthy adult subjects (Part B).
Interventions
- DRUG DZD9008 and intraconazole
- DRUG DZD9008 and carbamazepine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2022-01-25 |
| Est. Completion | 2022-12-08 |
| Phase | Phase 1 |
What the finished NCT05418582 record still lists
NCT05418582 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (33% lower).
The record links to 0 conditions, and to 2 interventions - of which DZD9008 and intraconazole is the first listed.
NCT05418582 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05418582 about?
NCT05418582 is a clinical study titled "Drug-drug Interactions Between DZD9008 and Itraconazole/Carbamazepine". This is a Phase 1, single-center, nonrandomized, open-label, 2-part, fixed-sequence, drug-drug interaction (DDI) study to assess the effect of multiple doses of itraconazole, a CYP3A4 enzyme inhibitor, on the single dose PK of DZD9008 in healthy adult subjects (Part A) and to assess the effect of mu...
What is the current status of trial NCT05418582?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2022-01-25. Estimated completion is 2022-12-08.
What interventions are being tested in trial NCT05418582?
The interventions under investigation include: DZD9008 and intraconazole (DRUG), DZD9008 and carbamazepine (DRUG).
Who is sponsoring clinical trial NCT05418582?
This trial is sponsored by Dizal Pharmaceuticals, which has 15 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05418582's enrollment target sits among peer trials
40 1130th of 2000 higher than 810 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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