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NCT05409105 · ClinicalTrials.gov registry record · NA
Mangoes and Exercise Inflammation
A NA study, sponsored by Appalachian State University.
- Completed
- Registry status
- NA
- Development phase
- 22
- Enrollment target
NCT05409105 is a NA study that has completed, run by Appalachian State University. The registered enrollment target is 22 participants.
The verdict
NCT05409105, a NA study, has completed, sponsored by Appalachian State University.
- COMPLETED
- Registry status
- NA
- Development phase
- 22 participants
- Enrollment target
Study Summary
Vigorous exercise bouts result in significant inflammation and muscle soreness. Our research group has published several papers showing that ingestion of various types of fruits enhances inflammation resolution after exercise. Mangoes have a unique nutrient profile (carotenoids, polyphenols, sugars, vitamins) that we hypothesize will mitigate post-exercise inflammation and muscle soreness. This study will examine the effect of 2 cups/day frozen mango ingestion (2 weeks, 330 g/day) in moderating exercise-induced (2.25 h cycling) inflammation and muscle soreness in a randomized crossover trial. Participants will include 20 male and female young adult cyclists (ages 18-60 years) who are capable of cycling 2.25 h in the laboratory on trainers. In random order, the cyclists will supplement their diets with 2 cups/day mangoes with 1 cup water or 1 cup water alone for two weeks, followed by the 2.25-h exercise challenge. Blood and urine samples will be collected pre- and post-2 weeks supplementation. Additional blood samples will be collected immediately post-exercise, and then 1.5-h, 3-h, and 24-h post-exercise. Urine samples will be analyzed for mango-related metabolites to confirm compliance to the supplementation regimen and to establish statistical relationships with inflammation-related outcomes. The blood samples will be analyzed for novel, cutting-edge outcomes related to inflammation including 70 oxylipins, inflammasome activation, and pro-inflammatory cytokines that we have previously shown are sensitive to exercise and nutrition-based interventions. If the data support our hypothesis, mango ingestion will be viewed as a nutritional strategy to counter exercise-induced inflammation by fitness enthusiasts and athletes who exercise vigorously on a regular basis.
Interventions
- DIETARY_SUPPLEMENT Water
- DIETARY_SUPPLEMENT Mangoes
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2022-08-15 |
| Est. Completion | 2023-01-30 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05409105
The ClinicalTrials.gov registry entry for NCT05409105 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 22 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Appalachian State University, which has 37 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Water is the first listed.
NCT05409105 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT05409105 about?
NCT05409105 is a clinical study titled "Mangoes and Exercise Inflammation". Vigorous exercise bouts result in significant inflammation and muscle soreness. Our research group has published several papers showing that ingestion of various types of fruits enhances inflammation resolution after exercise. Mangoes have a unique nutrient profile (carotenoids, polyphenols, sugars,...
What is the current status of trial NCT05409105?
This trial is currently completed. It is a NA study. The enrollment target is 22 participants. The study started on 2022-08-15. Estimated completion is 2023-01-30.
What interventions are being tested in trial NCT05409105?
The interventions under investigation include: Water (DIETARY_SUPPLEMENT), Mangoes (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT05409105?
This trial is sponsored by Appalachian State University, which has 37 total clinical trials registered on ClinicalTrials.gov.
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