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NCT05394467 · ClinicalTrials.gov registry record
Adipose Cellular Kinetics of Lipedema
A clinical trial of Lipedema, sponsored by Pennington Biomedical Research Center.
- Recruiting
- Registry status
- 24
- Enrollment target
- 1
- Study location
NCT05394467 is a study of Lipedema that is actively recruiting participants, run by Pennington Biomedical Research Center. The registered enrollment target is 24 participants, below the 211-participant average among 4 other Lipedema trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05394467, a study of Lipedema, is actively recruiting participants, sponsored by Pennington Biomedical Research Center.
- RECRUITING
- Registry status
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
Lipedema is characterized by an abnormal deposition of adipose tissue, resulting in fluid accumulation, limb enlargement, and pain. Lipedema is often misdiagnosed as simply obesity. A major challenge with diagnosis is the poorly understood biology underlying the disease. Limited studies suggest that the development of lipedema may involve adipocyte hypertrophy, increased commitment of adipose progenitor cells, hypoxia, adipocyte necrosis and macrophage recruitment. There remains an urgent need to investigate novel characteristics of adipose remodeling that may contribute to the pathogenesis of lipedema. The study investigators have reported quantitative measures of in vivo adipose kinetics using an 8-week incorporation of deuterium (administered as 2H2O) into the adipose tissue of women with obesity. The objective of this proposal is to utilize the metabolic 2H-labeling approach to measure, for the first time, in vivo adipocyte formation and triglyceride synthesis in the adipose tissue of participants with lipedema. Imaging approaches will provide a range of measurements to characterize the lipedema depots. The investigators hypothesize that lipedema adipose depots will have higher rates of adipocyte formation and triglyceride synthesis than both non-lipedema depots and those of women with traditional obesity. Lipedema may involve adipose tissue remodeling, characterized by adipocyte hypertrophy and increased commitment of preadipocytes and differentiation of adipocytes (adipogenesis), yielding an abundance of adipocytes with limited capacity to expand and accommodate lipid, resulting in hypoxia, macrophage recruitment, and local/systemic inflammation. Findings from this proposal will contribute to a better understanding of the pathogenesis of lipedema and may provide insight for the future development of therapeutic targets.
Conditions Studied
Study Locations (1)
Louisiana
- Pennington Biomedical Research Center - Baton Rouge
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2022-04-07 |
| Est. Completion | 2025-12-31 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05394467
The ClinicalTrials.gov registry entry for NCT05394467 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 211-participant average among 4 other Lipedema trials with a reported enrollment target (89% lower). The listed sponsor is Pennington Biomedical Research Center, which has 258 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Lipedema appearing as the primary indexed condition, and to 0 interventions.
NCT05394467 reports 1 study location spanning 1 distinct geographic area - top geographies include Louisiana.
Frequently Asked Questions
What is clinical trial NCT05394467 about?
NCT05394467 is a clinical study titled "Adipose Cellular Kinetics of Lipedema". Lipedema is characterized by an abnormal deposition of adipose tissue, resulting in fluid accumulation, limb enlargement, and pain. Lipedema is often misdiagnosed as simply obesity. A major challenge with diagnosis is the poorly understood biology underlying the disease. Limited studies suggest that...
What is the current status of trial NCT05394467?
This trial is currently recruiting. The enrollment target is 24 participants. The study started on 2022-04-07. Estimated completion is 2025-12-31.
What conditions does trial NCT05394467 study?
This clinical trial studies the following conditions: Lipedema.
Who is sponsoring clinical trial NCT05394467?
This trial is sponsored by Pennington Biomedical Research Center, which has 258 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05394467 being conducted?
This trial has 1 study location across Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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