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NCT05389644 · ClinicalTrials.gov registry record · NA
TMS as a Treatment for Apathy in Alzheimer's Disease
A NA study, sponsored by Massachusetts General Hospital.
- Terminated
- Registry status
- NA
- Development phase
- 3
- Enrollment target
NCT05389644: Clinical Trial NA study, sponsored by Massachusetts General Hospital.
NCT05389644 is a NA study that was terminated before completion, run by Massachusetts General Hospital. The registered enrollment target is 3 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05389644, a NA study, was terminated before completion, sponsored by Massachusetts General Hospital.
- TERMINATED
- Registry status
- NA
- Development phase
- 3 participants
- Enrollment target
Study Summary
This proposal will demonstrate that non-invasive brain stimulation is able to modulate cortico-striatal circuits in neurodegenerative patients with apathy, and that doing so results in circuit-specific increases in FC and DA availability. These circuit changes will be accompanied by changes in specific behavioral dimensions of apathy. This work will lead to larger studies which develop personalized, circuit-specific neuromodulation strategies for AD patients suffering from this intractable neuropsychiatric symptom.
Primary Outcome
Changes in circuit-specific FC will be assessed with functional magnetic resonance imaging (fMRI) before and after iTBS.
Interventions
- DEVICE Intermittent Theta Burst Stimulation (iTBS)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2024-05-02 |
| Est. Completion | 2024-10-28 |
| Phase | NA |
Why NCT05389644 stopped before completion
NCT05389644 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 3 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 1 intervention - of which Intermittent Theta Burst Stimulation (iTBS) is the first listed.
NCT05389644 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05389644 about?
NCT05389644 is a clinical study titled "TMS as a Treatment for Apathy in Alzheimer's Disease". This proposal will demonstrate that non-invasive brain stimulation is able to modulate cortico-striatal circuits in neurodegenerative patients with apathy, and that doing so results in circuit-specific increases in FC and DA availability. These circuit changes will be accompanied by changes in speci...
What is the current status of trial NCT05389644?
This trial is currently terminated. It is a NA study. The enrollment target is 3 participants. The study started on 2024-05-02. Estimated completion is 2024-10-28.
What interventions are being tested in trial NCT05389644?
The interventions under investigation include: Intermittent Theta Burst Stimulation (iTBS) (DEVICE).
Who is sponsoring clinical trial NCT05389644?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05389644's enrollment target sits among peer trials
3 1996th of 2000 higher than 4 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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