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NCT05383248 · ClinicalTrials.gov registry record · NA
Computational Cognitive Training To Boost Reward Responsiveness In Anhedonic Patients
A NA study, sponsored by University of California, San Diego.
- Completed
- Registry status
- NA
- Development phase
- 50
- Enrollment target
NCT05383248 is a NA study that has completed, run by University of California, San Diego. The registered enrollment target is 50 participants.
The verdict
NCT05383248, a NA study, has completed, sponsored by University of California, San Diego.
- COMPLETED
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
Study Summary
Anhedonia, i.e., reduced positive mood and decreased sensitivity to rewards, is observed in many psychiatric illnesses, particularly depression and anxiety disorders. Untreated anhedonia predicts worse clinical outcomes and poorer response to treatment, yet cognitive behavioral treatment approaches to target anhedonia are fraught with poor patient compliance in real-life settings. The proposed study aims to address this gap by 1) testing the usefulness of a non-invasive, computationally informed, cognitive training in boosting reward sensitivity and reducing anhedonia in depressed and anxious patients, and 2) delineating the neurocomputational mechanisms of change associated with such intervention. In other words, can we train the brain to obtain rewards and boost positive mood among depressed and anxious individuals? This project will help to develop a computational training protocol aimed at reducing anhedonia and improving existing interventions for psychiatric conditions characterized by reward processing deficits. Long-term goals include expanding this framework to a broader range of appetitive and social stimuli to develop precise cognitive training tools to treat anhedonia.
Interventions
- BEHAVIORAL High Reward - High Variance
- BEHAVIORAL High Reward - Low Variance
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2022-09-14 |
| Est. Completion | 2023-11-16 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05383248
The ClinicalTrials.gov registry entry for NCT05383248 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, San Diego, which has 775 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which High Reward - High Variance is the first listed.
NCT05383248 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT05383248 about?
NCT05383248 is a clinical study titled "Computational Cognitive Training To Boost Reward Responsiveness In Anhedonic Patients". Anhedonia, i.e., reduced positive mood and decreased sensitivity to rewards, is observed in many psychiatric illnesses, particularly depression and anxiety disorders. Untreated anhedonia predicts worse clinical outcomes and poorer response to treatment, yet cognitive behavioral treatment approaches ...
What is the current status of trial NCT05383248?
This trial is currently completed. It is a NA study. The enrollment target is 50 participants. The study started on 2022-09-14. Estimated completion is 2023-11-16.
What interventions are being tested in trial NCT05383248?
The interventions under investigation include: High Reward - High Variance (BEHAVIORAL), High Reward - Low Variance (BEHAVIORAL).
Who is sponsoring clinical trial NCT05383248?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
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