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NCT05357170 · ClinicalTrials.gov registry record
Microbiome Dysfunction in Surgical Intensive Care Unit Survivors
A clinical trial of Sepsis, Trauma Injury, sponsored by University of Florida.
- Recruiting
- Registry status
- 468
- Enrollment target
- 1
- Study location
NCT05357170: Recruiting study of Sepsis, Trauma Injury, sponsored by University of Florida.
NCT05357170 is a study of Sepsis, Trauma Injury that is actively recruiting participants, run by University of Florida. The registered enrollment target is 468 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05357170, a study of Sepsis, Trauma Injury, is actively recruiting participants, sponsored by University of Florida.
- RECRUITING
- Registry status
- 468 participants
- Enrollment target
- 1
- Study location
Study Summary
Oral and gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems. The topic of microbiome dysfunction after surgical intensive care admission is understudied but may be responsible for persistent systemic inflammation clinically observed in surgical intensive care patients. Therefore, the objective of this project is to investigate the oral and gut microbiome after the acute phase of sepsis, severe trauma injury, cardiopulmonary bypass, and major vascular surgery to compare with 108 age-matched healthy population controls
Primary Outcome
Identify oral and gut microbiome dysfunction through Microbial Taxonomic Analysis and Meta-transcriptomic Analysis
Conditions Studied
Interventions
- OTHER Human feces collection
Study Locations (1)
Florida
- UF Health at Shands Hospital - Gainesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 468 participants |
| Start Date | 2022-06-21 |
| Est. Completion | 2028-05-31 |
What NCT05357170 shows while recruiting
NCT05357170 is an observational study that tracks outcomes without assigning an intervention. The registered 468 participants enrollment target is mid-sized for trials with a published cap.
The record links to 1 condition, with Sepsis, Trauma Injury appearing as the primary indexed condition, and to 1 intervention - of which Human feces collection is the first listed.
NCT05357170 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT05357170 about?
NCT05357170 is a clinical study titled "Microbiome Dysfunction in Surgical Intensive Care Unit Survivors". Oral and gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems. The topic of microbiome dysfunction after surgical intensive care admission is understudied b...
What is the current status of trial NCT05357170?
This trial is currently recruiting. The enrollment target is 468 participants. The study started on 2022-06-21. Estimated completion is 2028-05-31.
What conditions does trial NCT05357170 study?
This clinical trial studies the following conditions: Sepsis, Trauma Injury.
What interventions are being tested in trial NCT05357170?
The interventions under investigation include: Human feces collection (OTHER).
Who is sponsoring clinical trial NCT05357170?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05357170 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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