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NCT05311735 · ClinicalTrials.gov registry record · NA
Mineralized and Partial Demineralized Dentin Graft Compared to FDBA
A NA study, sponsored by University of Oklahoma.
- Completed
- Registry status
- NA
- Development phase
- 45
- Enrollment target
NCT05311735: Completed NA study, sponsored by University of Oklahoma.
NCT05311735 is a NA study that has completed, run by University of Oklahoma. The registered enrollment target is 45 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05311735, a NA study, has completed, sponsored by University of Oklahoma.
- COMPLETED
- Registry status
- NA
- Development phase
- 45 participants
- Enrollment target
Study Summary
The bone grafting materials currently used in dentistry are autografts, allografts, xenografts, and alloplastic grafts. Among these different types of bone graft materials, autografts are considered to have the most predictable results due to its properties of osteogenesis, osteoinduction and osteoconduction. However, bone autografts are rarely used due to the high morbidity associated with harvesting the bone graft from the patient with a second surgical site. Because of the increased risk to the patient with autogenous bone grafts, the current standard of care is an allograft, which is a bone graft harvested from cadaver sources such as Freeze-Dried Bone Allograft (FDBA). While allografts can only possess the qualities of osteoinduction and osteoconduction, they also have dramatically less morbidity due to the lack of a second surgical site. Studies have shown that autogenous dentin grafts promote all three ideal mechanisms for bone regeneration. There are two methods to generate autogenous dentin grafts. One is to collect the extracted tooth and to send it to a tooth bank for the preparation process. The second is to process the extracted tooth in a clinical setting chairside, for a graft. A dentin graft can undergo different treatments such as demineralization, mineralization, and partial-demineralization. Although the autogenous dentin graft has shown positive results for bone regeneration, the comparison between partial-demineralized, mineralized autogenous dentin grafts, and freeze-dried bone grafts in the clinical setting for immediate grafting has not been studied in humans. Thus, there is a need to study the benefits of autogenous dentin partial-demineralized and mineralized grafts versus freeze-dried bone allografts regarding clinical, radiographically (bone volume and density), and efficacy results. This research addresses these areas of need.
Primary Outcome
Is there a clinical-radiographical difference in terms of bone volume between mineralized dentin grafts, partial demineralized tooth grafts and FDBA, as measured in millimeters, with calibrated devices?
Interventions
- PROCEDURE Freeze-Dried Bone Allograft control
- PROCEDURE Mineralized Dentin Graft
- PROCEDURE Partial-Demineralized Dentin Graft
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2021-10-29 |
| Est. Completion | 2024-06-19 |
| Phase | NA |
What the finished NCT05311735 record still lists
NCT05311735 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 45 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 3 interventions - of which Freeze-Dried Bone Allograft control is the first listed.
NCT05311735 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05311735 about?
NCT05311735 is a clinical study titled "Mineralized and Partial Demineralized Dentin Graft Compared to FDBA". The bone grafting materials currently used in dentistry are autografts, allografts, xenografts, and alloplastic grafts. Among these different types of bone graft materials, autografts are considered to have the most predictable results due to its properties of osteogenesis, osteoinduction and osteoc...
What is the current status of trial NCT05311735?
This trial is currently completed. It is a NA study. The enrollment target is 45 participants. The study started on 2021-10-29. Estimated completion is 2024-06-19.
What interventions are being tested in trial NCT05311735?
The interventions under investigation include: Freeze-Dried Bone Allograft control (PROCEDURE), Mineralized Dentin Graft (PROCEDURE), Partial-Demineralized Dentin Graft (PROCEDURE).
Who is sponsoring clinical trial NCT05311735?
This trial is sponsored by University of Oklahoma, which has 358 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05311735's enrollment target sits among peer trials
45 1411th of 2000 higher than 578 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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