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NCT05311735 · ClinicalTrials.gov registry record · NA
Mineralized and Partial Demineralized Dentin Graft Compared to FDBA
A NA study, sponsored by University of Oklahoma.
- Completed
- Registry status
- NA
- Development phase
- 45
- Enrollment target
NCT05311735 is a NA study that has completed, run by University of Oklahoma. The registered enrollment target is 45 participants.
The verdict
NCT05311735, a NA study, has completed, sponsored by University of Oklahoma.
- COMPLETED
- Registry status
- NA
- Development phase
- 45 participants
- Enrollment target
Study Summary
The bone grafting materials currently used in dentistry are autografts, allografts, xenografts, and alloplastic grafts. Among these different types of bone graft materials, autografts are considered to have the most predictable results due to its properties of osteogenesis, osteoinduction and osteoconduction. However, bone autografts are rarely used due to the high morbidity associated with harvesting the bone graft from the patient with a second surgical site. Because of the increased risk to the patient with autogenous bone grafts, the current standard of care is an allograft, which is a bone graft harvested from cadaver sources such as Freeze-Dried Bone Allograft (FDBA). While allografts can only possess the qualities of osteoinduction and osteoconduction, they also have dramatically less morbidity due to the lack of a second surgical site. Studies have shown that autogenous dentin grafts promote all three ideal mechanisms for bone regeneration. There are two methods to generate autogenous dentin grafts. One is to collect the extracted tooth and to send it to a tooth bank for the preparation process. The second is to process the extracted tooth in a clinical setting chairside, for a graft. A dentin graft can undergo different treatments such as demineralization, mineralization, and partial-demineralization. Although the autogenous dentin graft has shown positive results for bone regeneration, the comparison between partial-demineralized, mineralized autogenous dentin grafts, and freeze-dried bone grafts in the clinical setting for immediate grafting has not been studied in humans. Thus, there is a need to study the benefits of autogenous dentin partial-demineralized and mineralized grafts versus freeze-dried bone allografts regarding clinical, radiographically (bone volume and density), and efficacy results. This research addresses these areas of need.
Interventions
- PROCEDURE Freeze-Dried Bone Allograft control
- PROCEDURE Mineralized Dentin Graft
- PROCEDURE Partial-Demineralized Dentin Graft
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2021-10-29 |
| Est. Completion | 2024-06-19 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05311735
The ClinicalTrials.gov registry entry for NCT05311735 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 45 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Oklahoma, which has 358 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Freeze-Dried Bone Allograft control is the first listed.
NCT05311735 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT05311735 about?
NCT05311735 is a clinical study titled "Mineralized and Partial Demineralized Dentin Graft Compared to FDBA". The bone grafting materials currently used in dentistry are autografts, allografts, xenografts, and alloplastic grafts. Among these different types of bone graft materials, autografts are considered to have the most predictable results due to its properties of osteogenesis, osteoinduction and osteoc...
What is the current status of trial NCT05311735?
This trial is currently completed. It is a NA study. The enrollment target is 45 participants. The study started on 2021-10-29. Estimated completion is 2024-06-19.
What interventions are being tested in trial NCT05311735?
The interventions under investigation include: Freeze-Dried Bone Allograft control (PROCEDURE), Mineralized Dentin Graft (PROCEDURE), Partial-Demineralized Dentin Graft (PROCEDURE).
Who is sponsoring clinical trial NCT05311735?
This trial is sponsored by University of Oklahoma, which has 358 total clinical trials registered on ClinicalTrials.gov.
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