Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05302817 · ClinicalTrials.gov registry record · Phase 1
Functional Lung Avoidance Radiation Therapy Using Hyperpolarized Xenon-129 MRI
A Phase 1 study, sponsored by Xemed.
- Terminated
- Registry status
- Phase 1
- Development phase
- 9
- Enrollment target
NCT05302817: Clinical Trial Phase 1 study, sponsored by Xemed.
NCT05302817 is a Phase 1 study that was terminated before completion, run by Xemed. The registered enrollment target is 9 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (85% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05302817, a Phase 1 study, was terminated before completion, sponsored by Xemed.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 9 participants
- Enrollment target
Study Summary
Cancer radiation treatment plans that employ lung functional avoidance methods require 3D maps that differentiate regions of healthy lung function from regions of compromised tissue to deliver sufficient dose to the tumor while preserving as much functioning lung as possible. Hyperpolarized xenon-129 MRI can provide maps of ventilatory function and gas exchange to the bloodstream. Improving treatment plans based on this novel imaging modality could reduce risk or severity of radiation pneumonitis and improve post-treatment quality of life.
Primary Outcome
Phase 1 will assess safety of inhaling hyperpolarized xenon in this patient population with severely affected lung function.
Interventions
- COMBINATION_PRODUCT Hyperpolarized xenon MRI
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2023-03-17 |
| Est. Completion | 2025-02-28 |
| Phase | Phase 1 |
Why NCT05302817 stopped before completion
NCT05302817 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (85% lower).
The record links to 0 conditions, and to 1 intervention - of which Hyperpolarized xenon MRI is the first listed.
NCT05302817 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05302817 about?
NCT05302817 is a clinical study titled "Functional Lung Avoidance Radiation Therapy Using Hyperpolarized Xenon-129 MRI". Cancer radiation treatment plans that employ lung functional avoidance methods require 3D maps that differentiate regions of healthy lung function from regions of compromised tissue to deliver sufficient dose to the tumor while preserving as much functioning lung as possible. Hyperpolarized xenon-12...
What is the current status of trial NCT05302817?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 9 participants. The study started on 2023-03-17. Estimated completion is 2025-02-28.
What interventions are being tested in trial NCT05302817?
The interventions under investigation include: Hyperpolarized xenon MRI (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT05302817?
This trial is sponsored by Xemed, which has 5 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05302817's enrollment target sits among peer trials
9 1955th of 2000 higher than 42 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI