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NCT05277896 · ClinicalTrials.gov registry record · Phase 4
Randomized Trial of Sedative Choice for Intubation
A Phase 4 study, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- Phase 4
- Development phase
- 2,367
- Enrollment target
NCT05277896: Completed Phase 4 study, sponsored by Vanderbilt University Medical Center.
NCT05277896 is a Phase 4 study that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 2,367 participants, above the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (357% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05277896, a Phase 4 study, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 2,367 participants
- Enrollment target
Study Summary
Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death. The sedatives used to rapidly induce anesthesia for emergency tracheal intubation have been hypothesized to effect cardiovascular complications and patient outcomes, but the optimal sedative medication for intubation of critically ill adults remains unknown. Ketamine and etomidate are the two most commonly used sedatives during intubation of critically ill adults. Data from a randomized clinical trial are urgently needed to determine the effect of ketamine versus etomidate on cardiovascular complications and clinical outcomes of emergency tracheal intubation.
Interventions
- DRUG Ketamine
- DRUG Etomidate
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,367 participants |
| Start Date | 2022-04-06 |
| Est. Completion | 2025-09-06 |
| Phase | Phase 4 |
What the finished NCT05277896 record still lists
NCT05277896 is an interventional study that assigns participants to a tested intervention. Its 2,367 participants enrollment target places it among the larger protocols in the corpus, above the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (357% higher).
The record links to 0 conditions, and to 2 interventions - of which Ketamine is the first listed.
NCT05277896 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05277896 about?
NCT05277896 is a clinical study titled "Randomized Trial of Sedative Choice for Intubation". Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death. The sedatives used to rapidly induce anesthesia for emergency tracheal intubation have been hypothesized to effect cardiovascular complications and patient outcomes, bu...
What is the current status of trial NCT05277896?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 2,367 participants. The study started on 2022-04-06. Estimated completion is 2025-09-06.
What interventions are being tested in trial NCT05277896?
The interventions under investigation include: Ketamine (DRUG), Etomidate (DRUG).
Who is sponsoring clinical trial NCT05277896?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05277896's enrollment target sits among peer trials
2,367 31st of 2000 higher than 1,970 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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