Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05268302 · ClinicalTrials.gov registry record · Phase 1
Dengue 4 Human Infection Model (Dengue CVD 11000; DHIM-4)
A Phase 1 study, sponsored by University of Maryland, Baltimore.
- Completed
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
NCT05268302: Completed Phase 1 study, sponsored by University of Maryland, Baltimore.
NCT05268302 is a Phase 1 study that has completed, run by University of Maryland, Baltimore. The registered enrollment target is 20 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05268302, a Phase 1 study, has completed, sponsored by University of Maryland, Baltimore.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
Study Summary
The purpose of this research study is to test a weakened form of an experimental dengue virus challenge at different doses to test if participants develop symptoms or circulating virus in the blood (called viremia). When volunteers are exposed to dengue on purpose, it is called a "challenge" or Dengue Human Infection Model (DHIM). The research team is collecting information about the safety of the challenge and the best dose to use. The information may help us to make a dengue challenge (a DHIM) that will test vaccines to protect people from dengue.
Primary Outcome
solicited injection site adverse events until 7 days post virus inoculation
Interventions
- BIOLOGICAL Dengue 4 Live Virus Human Challenge (DENV-4-LVHC) - Low Dose
- BIOLOGICAL Dengue 4 Live Virus Human Challenge (DENV-4-LVHC) - Low Dose - Homologous Rechallenge
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2022-02-28 |
| Est. Completion | 2024-01-04 |
| Phase | Phase 1 |
What the finished NCT05268302 record still lists
NCT05268302 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower).
The record links to 0 conditions, and to 2 interventions - of which Dengue 4 Live Virus Human Challenge (DENV-4-LVHC) - Low Dose is the first listed.
NCT05268302 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05268302 about?
NCT05268302 is a clinical study titled "Dengue 4 Human Infection Model (Dengue CVD 11000; DHIM-4)". The purpose of this research study is to test a weakened form of an experimental dengue virus challenge at different doses to test if participants develop symptoms or circulating virus in the blood (called viremia). When volunteers are exposed to dengue on purpose, it is called a "challenge" or Deng...
What is the current status of trial NCT05268302?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2022-02-28. Estimated completion is 2024-01-04.
What interventions are being tested in trial NCT05268302?
The interventions under investigation include: Dengue 4 Live Virus Human Challenge (DENV-4-LVHC) - Low Dose (BIOLOGICAL), Dengue 4 Live Virus Human Challenge (DENV-4-LVHC) - Low Dose - Homologous Rechallenge (BIOLOGICAL).
Who is sponsoring clinical trial NCT05268302?
This trial is sponsored by University of Maryland, Baltimore, which has 560 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05268302's enrollment target sits among peer trials
20 1629th of 2000 higher than 285 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00573339 · 20 participants
Cardiac Magnetic Resonance Imaging (MRI) Normal Reference Control Group Testing
- NCT00692939 · 20 participants · Phase 1
Autologous Stem Cell Transplantation for Crohn's Disease
- NCT00967785 · 20 participants · Phase 1
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS
- NCT01406691 · 20 participants · Phase 4
Light Flashes to Treat Delayed Sleep Phase Disorder (DSPD)
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI