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NCT05263076 · ClinicalTrials.gov registry record · NA
Uterine Transplant for Women With Absolute Uterine Factor Infertility (AUFI)
A NA study of Mayer Rokitansky Kuster Hauser Syndrome and Infertility of Uterine Origin, sponsored by John Goss.
- Recruiting
- Registry status
- NA
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT05263076: Recruiting NA study of Mayer Rokitansky Kuster Hauser Syndrome and Infertility of Uterine Origin, sponsored by John Goss.
NCT05263076 is a NA study of Mayer Rokitansky Kuster Hauser Syndrome and Infertility of Uterine Origin that is actively recruiting participants, run by John Goss. The registered enrollment target is 10 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05263076, a NA study of Mayer Rokitansky Kuster Hauser Syndrome and Infertility of Uterine Origin, is actively recruiting participants, sponsored by John Goss.
- RECRUITING
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
Absolute Uterine Factor Infertility (AUFI) is due to congenital or surgical absence of a uterus or the presence of a nonfunctional uterus. Until 2014, the only option for women affected by Absolute Uterine Factor Infertility (AUFI) was adoption or surrogate motherhood. Uterine transplant is a new form of transplant to treat AUFI. The technique of uterus transplant was developed in Sweden with the transplantation of the uterus from a living donor to a woman affected by AUFI. Approximately 80 uterine transplantations have been performed, more than 50 of which have occurred within the past 3 years. To date, 34 children have been born from mothers who have received a living donor uterine transplant. This is a prospective study to treat Absolute Uterine Factor Infertility (AUFI) through uterine transplantation utilizing a uterus from a living or deceased donor resulting in live birth. A total of 10 biologically female (XX Karyotype) subjects will receive a uterine transplant.
Primary Outcome
A viable uterus is a uterine allograft that is fully procured and is suitable for transplantation into the recipient. This is measured at the time of procurement by visible inspection to ensure the vascular structures (uterine artery and vein) are not injured and the vaginal cuff is intact.
Conditions Studied
Interventions
- OTHER Uterine Transplant
Study Locations (1)
Texas
- Texas Children's Hospital - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2022-06-03 |
| Est. Completion | 2030-12 |
| Phase | NA |
What NCT05263076 shows while recruiting
NCT05263076 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 3 conditions, with Mayer Rokitansky Kuster Hauser Syndrome appearing as the primary indexed condition, and to 1 intervention - of which Uterine Transplant is the first listed.
NCT05263076 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05263076 about?
NCT05263076 is a clinical study titled "Uterine Transplant for Women With Absolute Uterine Factor Infertility (AUFI)". Absolute Uterine Factor Infertility (AUFI) is due to congenital or surgical absence of a uterus or the presence of a nonfunctional uterus. Until 2014, the only option for women affected by Absolute Uterine Factor Infertility (AUFI) was adoption or surrogate motherhood. Uterine transplant is a new fo...
What is the current status of trial NCT05263076?
This trial is currently recruiting. It is a NA study. The enrollment target is 10 participants. The study started on 2022-06-03. Estimated completion is 2030-12.
What conditions does trial NCT05263076 study?
This clinical trial studies the following conditions: Mayer Rokitansky Kuster Hauser Syndrome, Infertility of Uterine Origin, Absence of Uterus.
What interventions are being tested in trial NCT05263076?
The interventions under investigation include: Uterine Transplant (OTHER).
Who is sponsoring clinical trial NCT05263076?
This trial is sponsored by John Goss, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05263076 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05263076's enrollment target sits among peer trials
10 1928th of 2000 higher than 26 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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