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NCT05239598 · ClinicalTrials.gov registry record · Phase 2
Povidone-Iodine Oral Rinse Study
A Phase 2 study, sponsored by University of Pennsylvania.
- Completed
- Registry status
- Phase 2
- Development phase
- 40
- Enrollment target
NCT05239598: Completed Phase 2 study, sponsored by University of Pennsylvania.
NCT05239598 is a Phase 2 study that has completed, run by University of Pennsylvania. The registered enrollment target is 40 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (70% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05239598, a Phase 2 study, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 40 participants
- Enrollment target
Study Summary
This study is a two-arm, randomized, 2-phase study. Phase I will be double blinded clinical trial of the safety and efficacy of an antiseptic mouthwash solution on reducing SARS-CoV-2 load in COVID 19+ adult individuals. Phase II is designed as an open label trial, and all subjects will receive the active mouthwash.
Primary Outcome
The primary endpoint is the percentage reduction of SARS-Co-V-2 load in saliva at 60 minutes (post-intervention) compared to baseline between the PVP-I mouthwash versus the placebo mouthwash. For this outcome, Cycle Threshold is a proxy for SARS-Co-V-2 load. A positive percent change from baseline Cycle Threshold indicates a decrease from baseline SAR-Co-V2. \[Quick SARS-CoV-2 rRT-PCR Kit (Zymo Research, Cat. No. R3011)\].
Interventions
- DRUG Mouth rinse
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2022-02-07 |
| Est. Completion | 2022-07-13 |
| Phase | Phase 2 |
What the finished NCT05239598 record still lists
NCT05239598 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (70% lower).
The record links to 0 conditions, and to 1 intervention - of which Mouth rinse is the first listed.
NCT05239598 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05239598 about?
NCT05239598 is a clinical study titled "Povidone-Iodine Oral Rinse Study". This study is a two-arm, randomized, 2-phase study. Phase I will be double blinded clinical trial of the safety and efficacy of an antiseptic mouthwash solution on reducing SARS-CoV-2 load in COVID 19+ adult individuals. Phase II is designed as an open label trial, and all subjects will receive the ...
What is the current status of trial NCT05239598?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2022-02-07. Estimated completion is 2022-07-13.
What interventions are being tested in trial NCT05239598?
The interventions under investigation include: Mouth rinse (DRUG).
Who is sponsoring clinical trial NCT05239598?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05239598's enrollment target sits among peer trials
40 1362nd of 2000 higher than 542 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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