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NCT05227300 · ClinicalTrials.gov registry record · Phase 4
Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis
A Phase 4 study, sponsored by Indiana University.
- Completed
- Registry status
- Phase 4
- Development phase
- 40
- Enrollment target
NCT05227300: Completed Phase 4 study, sponsored by Indiana University.
NCT05227300 is a Phase 4 study that has completed, run by Indiana University. The registered enrollment target is 40 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (92% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05227300, a Phase 4 study, has completed, sponsored by Indiana University.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 40 participants
- Enrollment target
Study Summary
The purpose of this study is to determine whether one type of anesthetic (numbing medicine) will work better at numbing the nerve in a tooth than using a different type of anesthetic. A second purpose is to see if the time needed to numb the nerve in a tooth is different between the two anesthetics.
Primary Outcome
The mean Visual Analog Scale (VAS) score, which ranges from a min of 1 to a max of 10. In other words, inadequate anesthesia is considered to be a VAS score that is between 4 and 10 because that is not considered to be "comfortable and profound".
Interventions
- DRUG 2% lidocaine with 1:100,000 epinephrine
- DRUG Onset Sodium Bicarbonate Inj., 8.4%, USP Neutralizing Additive Solution
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2022-02-14 |
| Est. Completion | 2022-06-30 |
| Phase | Phase 4 |
What the finished NCT05227300 record still lists
NCT05227300 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (92% lower).
The record links to 0 conditions, and to 2 interventions - of which 2% lidocaine with 1:100,000 epinephrine is the first listed.
NCT05227300 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05227300 about?
NCT05227300 is a clinical study titled "Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis". The purpose of this study is to determine whether one type of anesthetic (numbing medicine) will work better at numbing the nerve in a tooth than using a different type of anesthetic. A second purpose is to see if the time needed to numb the nerve in a tooth is different between the two anesthetics.
What is the current status of trial NCT05227300?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 40 participants. The study started on 2022-02-14. Estimated completion is 2022-06-30.
What interventions are being tested in trial NCT05227300?
The interventions under investigation include: 2% lidocaine with 1:100,000 epinephrine (DRUG), Onset Sodium Bicarbonate Inj., 8.4%, USP Neutralizing Additive Solution (DRUG).
Who is sponsoring clinical trial NCT05227300?
This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05227300's enrollment target sits among peer trials
40 1397th of 2000 higher than 533 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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