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NCT05207397 · ClinicalTrials.gov registry record
Lactate for Energy and Neurocognition
A clinical trial, sponsored by University of Kansas Medical Center.
- Completed
- Registry status
- 24
- Enrollment target
NCT05207397 is a clinical trial that has completed, run by University of Kansas Medical Center. The registered enrollment target is 24 participants.
The verdict
NCT05207397 has completed, sponsored by University of Kansas Medical Center.
- COMPLETED
- Registry status
- 24 participants
- Enrollment target
Study Summary
Improved cardiorespiratory fitness following an aerobic exercise program elicits cognitive benefit in elderly subjects and memory improvement in Alzheimer's disease (AD). The physiological mechanism may be related to exercise-mediated change in circulating factors that permeate the brain. The response to each individual bout of exercise (i.e. the acute exercise response) may differ between subjects and be key to driving brain benefit. In young populations, the acute response to exercise can last hours and affect brain glucose metabolism. However, the field knows little about this acute exercise response in AD. Most exercise intervention trials designed to prevent and slow AD assess biomarkers at two fasting time points: pre- and post-intervention. The acute exercise response in the brain and periphery likely varies between subjects and diagnoses and provide key information regarding mechanisms of benefit. Our primary goals are to characterize the acute exercise response to exercise in the brain (glucose metabolism) and periphery (biomarker response) in aging and AD. We will identify relationships between exercise-related factors (i.e. heart rate, biomarkers) and change in brain metabolism and cognition. Understanding these mechanistic relationships will provide specific targets that can be used in future trials to develop individualized exercise prescriptions and maximize benefit.
Interventions
- OTHER Lactate infusion
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2023-04-12 |
| Est. Completion | 2024-03-29 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05207397
The ClinicalTrials.gov registry entry for NCT05207397 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Kansas Medical Center, which has 408 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Lactate infusion is the first listed.
NCT05207397 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT05207397 about?
NCT05207397 is a clinical study titled "Lactate for Energy and Neurocognition". Improved cardiorespiratory fitness following an aerobic exercise program elicits cognitive benefit in elderly subjects and memory improvement in Alzheimer's disease (AD). The physiological mechanism may be related to exercise-mediated change in circulating factors that permeate the brain. The respon...
What is the current status of trial NCT05207397?
This trial is currently completed. The enrollment target is 24 participants. The study started on 2023-04-12. Estimated completion is 2024-03-29.
What interventions are being tested in trial NCT05207397?
The interventions under investigation include: Lactate infusion (OTHER).
Who is sponsoring clinical trial NCT05207397?
This trial is sponsored by University of Kansas Medical Center, which has 408 total clinical trials registered on ClinicalTrials.gov.
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