Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05200845 · ClinicalTrials.gov registry record · NA
The Role of Altered Nutrient Partitioning in Food Reward
A NA study, sponsored by Virginia Polytechnic Institute and State University.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT05200845 is a NA study that has completed, run by Virginia Polytechnic Institute and State University. The registered enrollment target is 20 participants.
The verdict
NCT05200845, a NA study, has completed, sponsored by Virginia Polytechnic Institute and State University.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
Obesity remains a public health epidemic despite substantial advances in treatment strategies and therapies in the last decade. Effective strategies to support maintenance of improved metabolic health and reduced body weight are still needed. Signals from the gut to the brain are important in regulating metabolism and energy balance and have been linked with food reward and preference in metabolically healthy individuals with normal body mass index. In particular, post-ingestive signaling related to glucose metabolism has been linked with food reward and preference. However, not much is known about how these gut and brain signals interact to influence eating behaviors in states of obesity or altered metabolic health. In addition, evidence in rodent models and human studies indicates obesity is associated with a blunted brain response to foods compared with normal body weight. However, whether altered nutrient utilization, termed metabolic inflexibility, influences the relationship between obesity and food reward has yet to be studied. The overall objective of this proof-of-concept pilot study is to assess the feasibility of measuring reward response following a flavor-nutrient conditioning paradigm across the normal to obese body mass index (BMI) range and in states of altered metabolic health. The aims of this study are: 1) to determine whether differences in reinforcement learning/flavor-nutrient conditioning of carbohydrate can be measured across the body mass index range; and 2) to determine the feasibility of assessing metabolic flexibility and whether a relationship between metabolic flexibility and calorie-predictive reward can be detected.
Interventions
- OTHER Conditioned Stimulus + (CS+): Flavored beverage solution with 75 calories of sucrose
- OTHER Conditioned Stimulus - (CS-): Flavored beverage solution with sweetness-matched sucralose
- OTHER High-Fat Test Meal Inside a Metabolic Chamber
- OTHER High-Carbohydrate Test Meal Inside a Metabolic Chamber
- OTHER fMRI Scan
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2022-02-23 |
| Est. Completion | 2023-06-01 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05200845
The ClinicalTrials.gov registry entry for NCT05200845 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Virginia Polytechnic Institute and State University, which has 104 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 5 interventions - of which Conditioned Stimulus + (CS+): Flavored beverage solution with 75 calories of sucrose is the first listed.
NCT05200845 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT05200845 about?
NCT05200845 is a clinical study titled "The Role of Altered Nutrient Partitioning in Food Reward". Obesity remains a public health epidemic despite substantial advances in treatment strategies and therapies in the last decade. Effective strategies to support maintenance of improved metabolic health and reduced body weight are still needed. Signals from the gut to the brain are important in regul...
What is the current status of trial NCT05200845?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2022-02-23. Estimated completion is 2023-06-01.
What interventions are being tested in trial NCT05200845?
The interventions under investigation include: Conditioned Stimulus + (CS+): Flavored beverage solution with 75 calories of sucrose (OTHER), Conditioned Stimulus - (CS-): Flavored beverage solution with sweetness-matched sucralose (OTHER), High-Fat Test Meal Inside a Metabolic Chamber (OTHER), High-Carbohydrate Test Meal Inside a Metabolic Chamber (OTHER), fMRI Scan (OTHER).
Who is sponsoring clinical trial NCT05200845?
This trial is sponsored by Virginia Polytechnic Institute and State University, which has 104 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.