Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Study of Sacituzumab Govitecan Combinations in First-line Treatment of Participants With Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC)
NCT05186974 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this clinical study is to learn more about the study drug, sacituzumab govitecan-hziy (SG), and its dosing in combination with pembrolizumab or pembrolizumab and a platinum agent (carboplatin or cisplatin), in participants with advanced or metastatic (cancer that has spread) non-small-cell lung cancer (NSCLC).
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG Carboplatin
- DRUG Cisplatin
- DRUG Sacituzumab Govitecan-hziy (SG)
Study Locations (20)
California
- Beverly Hills Cancer Center — Beverly Hills
- USC/Norris Comprehensive Cancer Center — Los Angeles
- UCLA Hematology/Oncology - Santa Monica — Los Angeles
- UC Irvine Health — Orange
- Stanford Cancer Institute — Stanford
Illinois
- Northwestern Memorial Hospital — Chicago
- Rush University Medical Center — Chicago
- Orchard Healthcare Research Inc. — Skokie
New York
- Weill Cornell Medical/New York-Presbyterian Hospital — New York
- Great Lakes Cancer Care — Williamsville
North Carolina
- Wake Forest Baptist Health - High Point Medical Center — High Point
- FirstHealth Outpatient Cancer Center — Pinehurst
Alaska
- Alaska Oncology and Hematology, LLC. — Anchorage
Colorado
- University of Colorado Hospital - Anschutz Cancer Pavilion (ACP) — Aurora
District of Columbia
- Georgetown University Medical Center — Washington D.C.
Florida
- Moffitt Cancer Center — Tampa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 193 participants |
| Start Date | 2022-05-30 |
| Est. Completion | 2026-09 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05186974
The ClinicalTrials.gov registry entry for NCT05186974 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 193 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Gilead Sciences, which has 190 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Non-small Cell Lung Cancer appearing as the primary indexed condition, and to 4 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05186974 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Illinois, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05186974 about?
NCT05186974 is a clinical study titled "Study of Sacituzumab Govitecan Combinations in First-line Treatment of Participants With Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC)". The goal of this clinical study is to learn more about the study drug, sacituzumab govitecan-hziy (SG), and its dosing in combination with pembrolizumab or pembrolizumab and a platinum agent (carboplatin or cisplatin), in participants with advanced or metastatic (cancer that has spread) non-small-ce...
What is the current status of trial NCT05186974?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 193 participants. The study started on 2022-05-30. Estimated completion is 2026-09.
What conditions does trial NCT05186974 study?
This clinical trial studies the following conditions: Non-small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05186974?
The interventions under investigation include: Pembrolizumab (DRUG), Carboplatin (DRUG), Cisplatin (DRUG), Sacituzumab Govitecan-hziy (SG) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05186974?
This trial is sponsored by Gilead Sciences, which has 190 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05186974 being conducted?
This trial has 20 study locations across Alaska, California, Colorado, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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