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NCT05177991 · ClinicalTrials.gov registry record · Early Phase 1
Post-operative Pain Control-TAP Block Using Exparel vs. Marcaine for Hernia Repairs
A Early Phase 1 study of Ventral Hernia and Inguinal Hernia, sponsored by Leslie Son.
- Active
- Registry status
- Early Phase 1
- Development phase
- 200
- Enrollment target
- 1
- Study location
NCT05177991: Active Early Phase 1 study of Ventral Hernia and Inguinal Hernia, sponsored by Leslie Son.
NCT05177991 is a Early Phase 1 study of Ventral Hernia and Inguinal Hernia that is active but no longer recruiting, run by Leslie Son. The registered enrollment target is 200 participants, above the 132-participant average among 18 other Ventral Hernia trials with a reported enrollment target (52% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05177991, a Early Phase 1 study of Ventral Hernia and Inguinal Hernia, is active but no longer recruiting, sponsored by Leslie Son.
- ACTIVE NOT RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
While studies have shown improved postoperative pain control with TAP blocks after inguinal and ventral hernia repair, data comparing Liposomal bupivacaine (Exparel) to bupivacaine alone in formulation of the TAP block is particularly scarce. Therefore, we designed a prospective, randomized trial comparing the postoperative pain control in minimally invasive ventral and inguinal hernia repair patients who receive an Exaparel-based TAP block compared to the traditional bupivacaine (Marcaine) TAP block.
Primary Outcome
Lower mean daily post-operative pain scores between participants in the Exparel vs. Bupivacaine arms recorded multiple times over the observation period. The pain scale is 0-10 with 0 being no pain to 10 being the worst pain possible.
Conditions Studied
Interventions
- DRUG Bupivacaine
- DRUG Liposomal Bupivacaine
Study Locations (1)
Louisiana
- Karl LeBlanc - Baton Rouge
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2022-03-01 |
| Est. Completion | 2025-12-31 |
| Phase | Early Phase 1 |
What the registry record for NCT05177991 still lists
NCT05177991 is an interventional study that assigns participants to a tested intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, above the 132-participant average among 18 other Ventral Hernia trials with a reported enrollment target (52% higher).
The record links to 2 conditions, with Ventral Hernia appearing as the primary indexed condition, and to 2 interventions - of which Bupivacaine is the first listed.
NCT05177991 reports a single indexed study location in Louisiana.
Frequently Asked Questions
What is clinical trial NCT05177991 about?
NCT05177991 is a clinical study titled "Post-operative Pain Control-TAP Block Using Exparel vs. Marcaine for Hernia Repairs". While studies have shown improved postoperative pain control with TAP blocks after inguinal and ventral hernia repair, data comparing Liposomal bupivacaine (Exparel) to bupivacaine alone in formulation of the TAP block is particularly scarce. Therefore, we designed a prospective, randomized trial co...
What is the current status of trial NCT05177991?
This trial is currently active not recruiting. It is a Early Phase 1 study. The enrollment target is 200 participants. The study started on 2022-03-01. Estimated completion is 2025-12-31.
What conditions does trial NCT05177991 study?
This clinical trial studies the following conditions: Ventral Hernia, Inguinal Hernia.
What interventions are being tested in trial NCT05177991?
The interventions under investigation include: Bupivacaine (DRUG), Liposomal Bupivacaine (DRUG).
Who is sponsoring clinical trial NCT05177991?
This trial is sponsored by Leslie Son, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05177991 being conducted?
This trial has 1 study location across Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Ventral Hernia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05177991's enrollment target sits among peer trials
200 3rd of 18 higher than 14 of 18 other Ventral Hernia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Ventral Hernia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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