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NCT05156437 · ClinicalTrials.gov registry record · Phase 4
Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL)
A Phase 4 study, sponsored by West Virginia University.
- Terminated
- Registry status
- Phase 4
- Development phase
- 5
- Enrollment target
NCT05156437: Clinical Trial Phase 4 study, sponsored by West Virginia University.
NCT05156437 is a Phase 4 study that was terminated before completion, run by West Virginia University. The registered enrollment target is 5 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05156437, a Phase 4 study, was terminated before completion, sponsored by West Virginia University.
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 5 participants
- Enrollment target
Study Summary
The purpose of this study is to determine the safety and compliance of initial intravenous (IV) antibiotics followed by oral antibiotic therapy following uncomplicated IVDA endocarditis. Endocarditis has a high rate of sickness and death, involves a long hospitalization and a long-term use of IV antibiotics necessitating six (6) weeks of in-patient hospital stay, and comes with a high cost.
Primary Outcome
Incidences of all-cause mortality at six (6) months post-surgery.
Interventions
- DRUG Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin
- DRUG Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2022-03-16 |
| Est. Completion | 2024-10-31 |
| Phase | Phase 4 |
Why NCT05156437 stopped before completion
NCT05156437 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin is the first listed.
NCT05156437 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05156437 about?
NCT05156437 is a clinical study titled "Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL)". The purpose of this study is to determine the safety and compliance of initial intravenous (IV) antibiotics followed by oral antibiotic therapy following uncomplicated IVDA endocarditis. Endocarditis has a high rate of sickness and death, involves a long hospitalization and a long-term use of IV ant...
What is the current status of trial NCT05156437?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 5 participants. The study started on 2022-03-16. Estimated completion is 2024-10-31.
What interventions are being tested in trial NCT05156437?
The interventions under investigation include: Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin (DRUG), Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline (DRUG).
Who is sponsoring clinical trial NCT05156437?
This trial is sponsored by West Virginia University, which has 122 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05156437's enrollment target sits among peer trials
5 1989th of 2000 higher than 7 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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