Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05121168 · ClinicalTrials.gov registry record · Phase 4
Continuous Erector Spinae Plane Blocks to Treat Pain Following Percutaneous Nephrolithotomy
A Phase 4 study of Pain, Acute Postoperative and Renal Stone, sponsored by University of California, San Diego.
- Completed
- Registry status
- Phase 4
- Development phase
- 50
- Enrollment target
- 2
- Study locations
NCT05121168: Completed Phase 4 study of Pain, Acute Postoperative and Renal Stone, sponsored by University of California, San Diego.
NCT05121168 is a Phase 4 study of Pain, Acute Postoperative and Renal Stone that has completed, run by University of California, San Diego. The registered enrollment target is 50 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (90% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05121168, a Phase 4 study of Pain, Acute Postoperative and Renal Stone, has completed, sponsored by University of California, San Diego.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 50 participants
- Enrollment target
- 2
- Study locations
Study Summary
This is a randomized, triple-masked, placebo-controlled parallel-arm human subjects clinical trial investigating the addition of a continuous erector spinae plane nerve block to a single-injection erector spinae plane block to provide postoperative analgesia following percutaneous nephrolithotomy. Participants will all receive a single-injection nerve block and perineural catheter insertion. Following surgery, participants will be randomly allocated to receive either perineural local anesthetic or normal saline until the second day following surgery.
Primary Outcome
The numeric rating scale is a 0-10 Likert scale measuring pain level with 0 = no pain and 10 = worst imaginable pain scale. To claim that the addition of an ambulatory continuous erector spinae plane block is superior to a single-injection block alone, at least one of the two primary outcomes must be superior while the other at least non-inferior.
Conditions Studied
Interventions
- DRUG Active bupivacaine 0.25% via an erector spinae plane perineural catheter
- DRUG Placebo normal saline via an erector spinae plane perineural catheter
Study Locations (2)
California
- UC San Diego - San Diego
- University of California, San Diego - San Diego
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2022-03-16 |
| Est. Completion | 2025-11-08 |
| Phase | Phase 4 |
What the finished NCT05121168 record still lists
NCT05121168 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (90% lower).
The record links to 2 conditions, with Pain, Acute Postoperative appearing as the primary indexed condition, and to 2 interventions - of which Active bupivacaine 0.25% via an erector spinae plane perineural catheter is the first listed.
NCT05121168 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05121168 about?
NCT05121168 is a clinical study titled "Continuous Erector Spinae Plane Blocks to Treat Pain Following Percutaneous Nephrolithotomy". This is a randomized, triple-masked, placebo-controlled parallel-arm human subjects clinical trial investigating the addition of a continuous erector spinae plane nerve block to a single-injection erector spinae plane block to provide postoperative analgesia following percutaneous nephrolithotomy. P...
What is the current status of trial NCT05121168?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 50 participants. The study started on 2022-03-16. Estimated completion is 2025-11-08.
What conditions does trial NCT05121168 study?
This clinical trial studies the following conditions: Pain, Acute Postoperative, Renal Stone.
What interventions are being tested in trial NCT05121168?
The interventions under investigation include: Active bupivacaine 0.25% via an erector spinae plane perineural catheter (DRUG), Placebo normal saline via an erector spinae plane perineural catheter (DRUG).
Who is sponsoring clinical trial NCT05121168?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05121168 being conducted?
This trial has 2 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05121168's enrollment target sits among peer trials
50 1255th of 2000 higher than 679 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00200889 · 50 participants · Early Phase 1
Mapping Auricular Vagus Nerve Circuitry
- NCT00409435 · 50 participants · Phase 2
A Study of Pyridostigmine in Postural Tachycardia Syndrome
- NCT01202305 · 50 participants
The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies
- NCT01225913 · 50 participants · Phase 4
Mechanism(s) of Airflow Limitation During Exacerbation of Asthma
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI