Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT05037929 · ClinicalTrials.gov registry record · Phase 2

A Study to Evaluate the Efficacy and Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease

A Phase 2 study, sponsored by Genentech.

Completed
Registry status
Phase 2
Development phase
1,334
Enrollment target

NCT05037929: Completed Phase 2 study, sponsored by Genentech.

NCT05037929 is a Phase 2 study that has completed, run by Genentech. The registered enrollment target is 1,334 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (903% higher). According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT05037929, a Phase 2 study, has completed, sponsored by Genentech.

COMPLETED
Registry status
Phase 2
Development phase
1,334 participants
Enrollment target

Study Summary

This study will evaluate the efficacy, safety, and pharmacokinetics of astegolimab in combination with standard of care chronic obstructive pulmonary disease (COPD) maintenance therapy in patients with COPD who are former or current smokers and have a history of frequent exacerbations.

Interventions

  • DRUG Placebo
  • DRUG Astegolimab

Trial Details

FieldValue
Enrollment Target 1,334 participants
Start Date 2021-10-05
Est. Completion 2025-07-07
Phase Phase 2
Genentech

332 total trials

What the finished NCT05037929 record still lists

NCT05037929 is an interventional study that assigns participants to a tested intervention. Its 1,334 participants enrollment target places it among the larger protocols in the corpus, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (903% higher).

The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.

NCT05037929 does not publish any study locations in the registry export this page uses.

Frequently Asked Questions

What is clinical trial NCT05037929 about?

NCT05037929 is a clinical study titled "A Study to Evaluate the Efficacy and Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease". This study will evaluate the efficacy, safety, and pharmacokinetics of astegolimab in combination with standard of care chronic obstructive pulmonary disease (COPD) maintenance therapy in patients with COPD who are former or current smokers and have a history of frequent exacerbations.

What is the current status of trial NCT05037929?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 1,334 participants. The study started on 2021-10-05. Estimated completion is 2025-07-07.

What interventions are being tested in trial NCT05037929?

The interventions under investigation include: Placebo (DRUG), Astegolimab (DRUG).

Who is sponsoring clinical trial NCT05037929?

This trial is sponsored by Genentech, which has 332 total clinical trials registered on ClinicalTrials.gov.

How this trial's enrollment target compares

Where NCT05037929's enrollment target sits among peer trials

1,334 13th of 2000 higher than 1,988 of 2,000 other Phase 2 trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT06972056 · 1,335 participants · Phase 4

    Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

  • NCT05415761 · 1,332 participants · NA

    Comparative Effectiveness of Mobile Health Smoking Cessation Approaches Among Underserved Patients in Primary Care

  • NCT05511298 · 1,332 participants

    Empowering Students Project

  • NCT06934876 · 1,332 participants

    Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults

Similar registry start date

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

  • NCT07125183 · started 2026-12 · Phase 2

    Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

  • NCT07292298 · started 2026-11 · Phase 2

    Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

  • NCT04263285 · started 2026-10 · NA

    Treatment of Depression Post-SCI

Source: ClinicalTrials.gov NCT05037929, the US trial registry maintained by the National Library of Medicine. NCT05037929 (large enrollment · none site footprint · completed) retrieved and formatted by PlainTrial, see methodology.