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NCT05025800 · ClinicalTrials.gov registry record · Phase 1

ALX148, Rituximab and Lenalidomide for the Treatment of Indolent and Aggressive B-cell Non-Hodgkin Lymphoma

A Phase 1 study of Indolent B-Cell Non-Hodgkin Lymphoma and Ann Arbor Stage III Grade 2 Follicular Lymphoma, sponsored by M.D. Anderson Cancer Center.

Active
Registry status
Phase 1
Development phase
47
Enrollment target
1
Study location

NCT05025800: Active Phase 1 study of Indolent B-Cell Non-Hodgkin Lymphoma and Ann Arbor Stage III Grade 2 Follicular Lymphoma, sponsored by M.D. Anderson Cancer Center.

NCT05025800 is a Phase 1 study of Indolent B-Cell Non-Hodgkin Lymphoma and Ann Arbor Stage III Grade 2 Follicular Lymphoma that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 47 participants, below the 64-participant average among 6 other Indolent B-Cell Non-Hodgkin Lymphoma trials with a reported enrollment target (27% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05025800, a Phase 1 study of Indolent B-Cell Non-Hodgkin Lymphoma and Ann Arbor Stage III Grade 2 Follicular Lymphoma, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.

ACTIVE NOT RECRUITING
Registry status
Phase 1
Development phase
47 participants
Enrollment target
1
Study location

Study Summary

This phase I/II trial finds out the best dose, possible benefits and/or side effects of ALX148 in combination with rituximab and lenalidomide in treating patients with indolent and aggressive B-cell non-Hodgkin lymphoma. Immunotherapy with ALX148, may induce changes in body's immune system and may interfere with the ability of cancer cells to grow and spread. Chemotherapy drugs, such as lenalidomide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Rituximab is a monoclonal antibody that binds to a protein called CD20 found on B-cells, and may kill cancer cells. Giving ALX148 in combination with rituximab and lenalidomide may help to control the disease.

Conditions Studied

Indolent B-Cell Non-Hodgkin Lymphoma Ann Arbor Stage III Grade 2 Follicular Lymphoma Ann Arbor Stage III Grade 3 Follicular Lymphoma Ann Arbor Stage IV Grade 1 Follicular Lymphoma Ann Arbor Stage III Marginal Zone Lymphoma Ann Arbor Stage IV Marginal Zone Lymphoma Aggressive B-Cell Non-Hodgkin Lymphoma Ann Arbor Stage IV Grade 2 Follicular Lymphoma Ann Arbor Stage IV Grade 3 Follicular Lymphoma Composite Lymphoma

Interventions

  • DRUG Lenalidomide
  • BIOLOGICAL Rituximab
  • DRUG CD47 Antagonist ALX148

Study Locations (1)

Texas

  • M D Anderson Cancer Center - Houston

Trial Details

FieldValue
Enrollment Target 47 participants
Start Date 2021-10-13
Est. Completion 2028-03-21
Phase Phase 1
M.D. Anderson Cancer Center

2,692 total trials

What the registry record for NCT05025800 still lists

NCT05025800 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 47 participants, a relatively small participant target, below the 64-participant average among 6 other Indolent B-Cell Non-Hodgkin Lymphoma trials with a reported enrollment target (27% lower).

The record links to 10 conditions, with Indolent B-Cell Non-Hodgkin Lymphoma appearing as the primary indexed condition, and to 3 interventions - of which Lenalidomide is the first listed.

NCT05025800 reports a single indexed study location in Texas.

Frequently Asked Questions

What is clinical trial NCT05025800 about?

NCT05025800 is a clinical study titled "ALX148, Rituximab and Lenalidomide for the Treatment of Indolent and Aggressive B-cell Non-Hodgkin Lymphoma". This phase I/II trial finds out the best dose, possible benefits and/or side effects of ALX148 in combination with rituximab and lenalidomide in treating patients with indolent and aggressive B-cell non-Hodgkin lymphoma. Immunotherapy with ALX148, may induce changes in body's immune system and may i...

What is the current status of trial NCT05025800?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 47 participants. The study started on 2021-10-13. Estimated completion is 2028-03-21.

What conditions does trial NCT05025800 study?

This clinical trial studies the following conditions: Indolent B-Cell Non-Hodgkin Lymphoma, Ann Arbor Stage III Grade 2 Follicular Lymphoma, Ann Arbor Stage III Grade 3 Follicular Lymphoma, Ann Arbor Stage IV Grade 1 Follicular Lymphoma, Ann Arbor Stage III Marginal Zone Lymphoma.

What interventions are being tested in trial NCT05025800?

The interventions under investigation include: Lenalidomide (DRUG), Rituximab (BIOLOGICAL), CD47 Antagonist ALX148 (DRUG).

Who is sponsoring clinical trial NCT05025800?

This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05025800 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Related registry views

Source: ClinicalTrials.gov NCT05025800, the US trial registry maintained by the National Library of Medicine. NCT05025800 (small enrollment · single site footprint · active not recruiting) retrieved and formatted by PlainTrial, see methodology.