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NCT05017428 · ClinicalTrials.gov registry record · NA
Absorption and Digestion Kinetics of Human Metabolites
A NA study of Postprandial Inflammation, sponsored by University of California, Davis.
- Completed
- Registry status
- NA
- Development phase
- 5
- Enrollment target
- 1
- Study location
NCT05017428 is a NA study of Postprandial Inflammation that has completed, run by University of California, Davis. The registered enrollment target is 5 participants. The trial reports 1 study location across 1 state.
The verdict
NCT05017428, a NA study of Postprandial Inflammation, has completed, sponsored by University of California, Davis.
- COMPLETED
- Registry status
- NA
- Development phase
- 5 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this pilot study is to evaluate the effects oral supplementation with four human metabolites (spermidine, nicotinamide, palmitoylethanolamide (PEA), and oleoylethanolamide(OEA)) at varying doses on the circulating blood levels of these metabolites as well as their immediate effects on plasma functionality and postprandial inflammation. 5 young healthy subjects will participate in a four armed study consisting of a Placebo arm and a Low, Medium, and High Dose arm. Subjects will be given a standardized breakfast along with supplementation with either an escalating dose (Low: 1x, Medium: 2x, High: 3x) of a combination of spermidine, nicotinamide, PEA and OEA or a placebo control and a time course of their blood plasma will be collected after supplementation. Plasma samples will be assessed for their concentration of spermidine, nicotinamide, PEA, and OEA as well as their experimental and clinical functionalities including their anti-inflammatory, antioxidant, and cholesterol efflux abilities on primary human macrophage.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Spermidine
- DIETARY_SUPPLEMENT Nicotinamide
- DIETARY_SUPPLEMENT PEA
- DIETARY_SUPPLEMENT OEA
- DIETARY_SUPPLEMENT Wheat Flour
Study Locations (1)
California
- University of California Davis - Davis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2021-04-08 |
| Est. Completion | 2021-07-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05017428
The ClinicalTrials.gov registry entry for NCT05017428 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 5 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, Davis, which has 657 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Postprandial Inflammation appearing as the primary indexed condition, and to 5 interventions - of which Spermidine is the first listed.
NCT05017428 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT05017428 about?
NCT05017428 is a clinical study titled "Absorption and Digestion Kinetics of Human Metabolites". The purpose of this pilot study is to evaluate the effects oral supplementation with four human metabolites (spermidine, nicotinamide, palmitoylethanolamide (PEA), and oleoylethanolamide(OEA)) at varying doses on the circulating blood levels of these metabolites as well as their immediate effects on...
What is the current status of trial NCT05017428?
This trial is currently completed. It is a NA study. The enrollment target is 5 participants. The study started on 2021-04-08. Estimated completion is 2021-07-01.
What conditions does trial NCT05017428 study?
This clinical trial studies the following conditions: Postprandial Inflammation.
What interventions are being tested in trial NCT05017428?
The interventions under investigation include: Spermidine (DIETARY_SUPPLEMENT), Nicotinamide (DIETARY_SUPPLEMENT), PEA (DIETARY_SUPPLEMENT), OEA (DIETARY_SUPPLEMENT), Wheat Flour (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT05017428?
This trial is sponsored by University of California, Davis, which has 657 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05017428 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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