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NCT05017428 · ClinicalTrials.gov registry record · NA
Absorption and Digestion Kinetics of Human Metabolites
A NA study of Postprandial Inflammation, sponsored by University of California, Davis.
- Completed
- Registry status
- NA
- Development phase
- 5
- Enrollment target
- 1
- Study location
NCT05017428: Completed NA study of Postprandial Inflammation, sponsored by University of California, Davis.
NCT05017428 is a NA study of Postprandial Inflammation that has completed, run by University of California, Davis. The registered enrollment target is 5 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05017428, a NA study of Postprandial Inflammation, has completed, sponsored by University of California, Davis.
- COMPLETED
- Registry status
- NA
- Development phase
- 5 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this pilot study is to evaluate the effects oral supplementation with four human metabolites (spermidine, nicotinamide, palmitoylethanolamide (PEA), and oleoylethanolamide(OEA)) at varying doses on the circulating blood levels of these metabolites as well as their immediate effects on plasma functionality and postprandial inflammation. 5 young healthy subjects will participate in a four armed study consisting of a Placebo arm and a Low, Medium, and High Dose arm. Subjects will be given a standardized breakfast along with supplementation with either an escalating dose (Low: 1x, Medium: 2x, High: 3x) of a combination of spermidine, nicotinamide, PEA and OEA or a placebo control and a time course of their blood plasma will be collected after supplementation. Plasma samples will be assessed for their concentration of spermidine, nicotinamide, PEA, and OEA as well as their experimental and clinical functionalities including their anti-inflammatory, antioxidant, and cholesterol efflux abilities on primary human macrophage.
Primary Outcome
Quantitative plasma concentrations of spermidine, nicotinamide, pamitoylethanolamide, and oleoylethanolamide (in nmol/L).
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Spermidine
- DIETARY_SUPPLEMENT Nicotinamide
- DIETARY_SUPPLEMENT PEA
- DIETARY_SUPPLEMENT OEA
- DIETARY_SUPPLEMENT Wheat Flour
Study Locations (1)
California
- University of California Davis - Davis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2021-04-08 |
| Est. Completion | 2021-07-01 |
| Phase | NA |
What the finished NCT05017428 record still lists
NCT05017428 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Postprandial Inflammation appearing as the primary indexed condition, and to 5 interventions - of which Spermidine is the first listed.
NCT05017428 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05017428 about?
NCT05017428 is a clinical study titled "Absorption and Digestion Kinetics of Human Metabolites". The purpose of this pilot study is to evaluate the effects oral supplementation with four human metabolites (spermidine, nicotinamide, palmitoylethanolamide (PEA), and oleoylethanolamide(OEA)) at varying doses on the circulating blood levels of these metabolites as well as their immediate effects on...
What is the current status of trial NCT05017428?
This trial is currently completed. It is a NA study. The enrollment target is 5 participants. The study started on 2021-04-08. Estimated completion is 2021-07-01.
What conditions does trial NCT05017428 study?
This clinical trial studies the following conditions: Postprandial Inflammation.
What interventions are being tested in trial NCT05017428?
The interventions under investigation include: Spermidine (DIETARY_SUPPLEMENT), Nicotinamide (DIETARY_SUPPLEMENT), PEA (DIETARY_SUPPLEMENT), OEA (DIETARY_SUPPLEMENT), Wheat Flour (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT05017428?
This trial is sponsored by University of California, Davis, which has 657 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05017428 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05017428's enrollment target sits among peer trials
5 1988th of 2000 higher than 5 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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