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NCT05010473 · ClinicalTrials.gov registry record · NA
Cortical Contributions to Frequency Following Responses and Modulation
A NA study, sponsored by Northwestern University.
- Completed
- Registry status
- NA
- Development phase
- 73
- Enrollment target
NCT05010473: Completed NA study, sponsored by Northwestern University.
NCT05010473 is a NA study that has completed, run by Northwestern University. The registered enrollment target is 73 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05010473, a NA study, has completed, sponsored by Northwestern University.
- COMPLETED
- Registry status
- NA
- Development phase
- 73 participants
- Enrollment target
Study Summary
The frequency-following response (FFR), a scalp-recorded neurophonic potential, is a widely used metric of speech encoding integrity in healthy and clinical human populations. The translational potential of the FFR as a biomarker is constrained by poor understanding of its neural generators and influencing factors. This study leverages a cross-species and cross-level approach to provide mechanistic insight into the properties of the cortical source of the FFR, and elucidate the role of cortical feedback via cortico-collicular projections on modulation of the FFR as a function of stimulus context, arousal state, and category relevance. This clinical trial will focus on the influences of category relevance, predictability, and participant arousal state on the FFRs in neurotypical human participants.
Primary Outcome
The similarity between the stimulus and the FFR will be evaluated. The pitch tracking ability will be estimated by comparing the sliding window autocorrelation pitch tracks of the stimulus and FFR. Machine learning models will be trained to decode FFR to different stimulus categories based on pitch height and pitch direction. The chance estimates of the decoding accuracies will be estimated.
Interventions
- BEHAVIORAL Speech and non-speech sound stimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 73 participants |
| Start Date | 2022-01-20 |
| Est. Completion | 2026-03-04 |
| Phase | NA |
What the finished NCT05010473 record still lists
NCT05010473 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 73 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 1 intervention - of which Speech and non-speech sound stimulation is the first listed.
NCT05010473 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05010473 about?
NCT05010473 is a clinical study titled "Cortical Contributions to Frequency Following Responses and Modulation". The frequency-following response (FFR), a scalp-recorded neurophonic potential, is a widely used metric of speech encoding integrity in healthy and clinical human populations. The translational potential of the FFR as a biomarker is constrained by poor understanding of its neural generators and infl...
What is the current status of trial NCT05010473?
This trial is currently completed. It is a NA study. The enrollment target is 73 participants. The study started on 2022-01-20. Estimated completion is 2026-03-04.
What interventions are being tested in trial NCT05010473?
The interventions under investigation include: Speech and non-speech sound stimulation (BEHAVIORAL).
Who is sponsoring clinical trial NCT05010473?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05010473's enrollment target sits among peer trials
73 1089th of 2000 higher than 912 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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