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NCT05006807 · ClinicalTrials.gov registry record
Comparison Neuromuscular Blockade Monitors
A clinical trial, sponsored by University of Washington.
- Completed
- Registry status
- 51
- Enrollment target
NCT05006807: Completed study, sponsored by University of Washington.
NCT05006807 is a clinical trial that has completed, run by University of Washington. The registered enrollment target is 51 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05006807 has completed, sponsored by University of Washington.
- COMPLETED
- Registry status
- 51 participants
- Enrollment target
Study Summary
The overall objective of this research is to evaluate different laboratory-built and commercially available sensors used to measure the effects of neuromuscular blocking drugs on neuromuscular function during surgery, by measuring evoked thumb twitch response to ulnar nerve stimulation (also known as "twitch monitoring"). The specific aim is to compare mechanomyography, which is the "gold standard" laboratory measurement to assess neuromuscular blockade, to the sensors used in commercially available neuromuscular blockade monitors, such as acceleromyography and electromyography. The study endpoints are the train-of-four count (TOFC), the ratio of the height of the 4th twitch to the height of the 1st twitch (train-of-four ratio, TOFR), and the post tetanic count (PTC). The mechanomyography devices have been constructed in our laboratory and are not commercially available.
Primary Outcome
Determine evoked thumb twitch response to ulnar nerve train-of-four stimulation then determine the ratio of the amplitude of the fourth twitch divided by the first twitch, referred to as the train-of-four ratio. The train-of-four ratio is expected to be 1.0 in the absence of neuromuscular blocking drugs. The range of possible train-of-four ratios is 0-1.6. Results that deviate from a train-of-four ratio of 1.0 represent inaccuracy of the measurement.
Interventions
- DEVICE Mechanomyograph Twitch Monitor
- DEVICE Stimpod Twitch Monitor
- DEVICE TetraGraph Twitch Monitor
- DEVICE TwitchView Twitch Monitor
- DEVICE Nihon Kohden Twitch Monitor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 51 participants |
| Start Date | 2022-02-01 |
| Est. Completion | 2024-12-01 |
What the finished NCT05006807 record still lists
NCT05006807 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 51 participants, a relatively small participant target.
The record links to 0 conditions, and to 5 interventions - of which Mechanomyograph Twitch Monitor is the first listed.
NCT05006807 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05006807 about?
NCT05006807 is a clinical study titled "Comparison Neuromuscular Blockade Monitors". The overall objective of this research is to evaluate different laboratory-built and commercially available sensors used to measure the effects of neuromuscular blocking drugs on neuromuscular function during surgery, by measuring evoked thumb twitch response to ulnar nerve stimulation (also known a...
What is the current status of trial NCT05006807?
This trial is currently completed. The enrollment target is 51 participants. The study started on 2022-02-01. Estimated completion is 2024-12-01.
What interventions are being tested in trial NCT05006807?
The interventions under investigation include: Mechanomyograph Twitch Monitor (DEVICE), Stimpod Twitch Monitor (DEVICE), TetraGraph Twitch Monitor (DEVICE), TwitchView Twitch Monitor (DEVICE), Nihon Kohden Twitch Monitor (DEVICE).
Who is sponsoring clinical trial NCT05006807?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
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